178685-33-1

178685-33-1 structure

Name: Azide-PEG3-Tos
Chemical Name: 8-azido-3,6-dioxaoctyl tosylate
CAS Number: 178685-33-1
Molecular Formula: C₁₃H₁₉N₃O₅S
Molecular Weight: 329.37200
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-06-07 15:24:54
Modify Date: 2024-01-10 10:32:04
Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name	8-azido-3,6-dioxaoctyl tosylate
Synonyms	2-(2-(2-azidoethoxy)ethoxy)ethyl toluenesulfonate toluene 4-sulfonic acid 2-[2-(2-azidoethoxy)ethoxy] ethyl ester 2-[2-(2-azidoethoxy)ethoxy]ethyl 4-methylbenzenesulfonate 2-(2-(2-azidoethoxy)ethoxy)ethyl tosylate α-azidodeoxy-ω-O-tosyltriethyleneglycol 2-(2-(2-azidoethoxy)ethoxy)ethyl 4-methylbenzenesulfonate Toluene-4-sulfonic acid 2-[2-(2-azido-ethoxy)-ethoxy]-ethyl ester

Description	Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References	[1]. Borchmann DE, et al. GRGDS-Functionalized Poly(lactide)-graft-poly(ethylene glycol) Copolymers: Combining Thiol-Ene Chemistry with Staudinger Ligation. Macromolecules. 2013 Jun 11;46(11):4426-4431. [2]. Park, Tae Kyo, et al. Compound bearing beta-galactoside-introduced self-immolative linker. WO2018124758A2.