87827-02-9

87827-02-9 structure

Name: 3-(2'-phenyl-2'-Cyclopentyl-2'-hydroxyethoxy)quinuclidine
Chemical Name: 2-(1-azabicyclo[2.2.2]octan-3-yloxy)-1-cyclopentyl-1-phenylethanol
CAS Number: 87827-02-9
Molecular Formula: C₂₀H₂₉NO₂
Molecular Weight: 315.450
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2018-12-13 17:48:02
Modify Date: 2025-08-20 10:26:35
Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1][2].

Name	2-(1-azabicyclo[2.2.2]octan-3-yloxy)-1-cyclopentyl-1-phenylethanol
Synonyms	2-(1-Azabicyclo[2.2.2]oct-3-yloxy)-1-cyclopentyl-1-phenylethanol Benzenemethanol, α-((1-azabicyclo(2.2.2)oct-3-yloxy)methyl)-α-cyclopentyl- UNII:353CX8CSHD Benzenemethanol, α-[(1-azabicyclo[2.2.2]oct-3-yloxy)methyl]-α-cyclopentyl- m 8218 3-(2'-phenyl-2'-Cyclopentyl-2'-hydroxyethoxy)quinuclidine

Description	Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Inflammation/Immunology
Target	NF-κB
References	[1]. Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885. [2]. Xiao HT, et al. Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors. Drug Des Devel Ther. 2012;6:317-22.