1440209-96-0
1440209-96-0 structure
- Name: BRD 73954
- Chemical Name: N-Hydroxy-N'-(2-phenylethyl)isophthalamide
- CAS Number: 1440209-96-0
- Molecular Formula: C16H16N2O3
- Molecular Weight: 284.31000
- Catalog: Biochemical Inhibitor Epigenetics HDAC inhibitor
- Create Date: 2018-04-29 20:40:39
- Modify Date: 2024-01-09 20:15:29
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BRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.IC50 value: 36 nM (HDAC6), 120 nM (HDAC8)Target: HDACBRD73954 is the first small molecule histone deacetylase (HDAC) inhibitor, capable of potently and selectively inhibiting both HDAC6 and HDAC8, despite the fact that these isoforms belong to distinct phylogenetic classes within the HDAC family of enzymes. Our data demonstrate that meta substituents of phenyl hydroxamic acids are readily accommodated upon binding to HDAC6 and, furthermore, are necessary for the potent inhibition of HDAC8. At 10 ?M, BRD73954 treatment results in a robust increase in acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, 2, and 3, in HeLa cells.
| Name | N-Hydroxy-N'-(2-phenylethyl)isophthalamide |
|---|---|
| Synonyms |
N-Hydroxy-N'-(2-phenylethyl)isophthalamide
1,3-Benzenedicarboxamide, N-hydroxy-N-(2-phenylethyl)- BRD73954 |
| Description | BRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.IC50 value: 36 nM (HDAC6), 120 nM (HDAC8)Target: HDACBRD73954 is the first small molecule histone deacetylase (HDAC) inhibitor, capable of potently and selectively inhibiting both HDAC6 and HDAC8, despite the fact that these isoforms belong to distinct phylogenetic classes within the HDAC family of enzymes. Our data demonstrate that meta substituents of phenyl hydroxamic acids are readily accommodated upon binding to HDAC6 and, furthermore, are necessary for the potent inhibition of HDAC8. At 10 ?M, BRD73954 treatment results in a robust increase in acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, 2, and 3, in HeLa cells. |
|---|---|
| Related Catalog | |
| Target |
HDAC6:0.036 μM (IC50) HDAC8:0.12 μM (IC50) HDAC2:9 μM (IC50) |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C16H16N2O3 |
| Molecular Weight | 284.31000 |
| Exact Mass | 284.11600 |
| PSA | 78.43000 |
| LogP | 1.19 |
| Index of Refraction | 1.613 |
| Storage condition | -20℃ |
| RIDADR | NONH for all modes of transport |
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