142449-89-6

142449-89-6 structure

Name: Vitisin A
Chemical Name: (+)-vitisin A
CAS Number: 142449-89-6
Molecular Formula: C₅₆H₄₂O₁₂
Molecular Weight: 906.93
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2018-06-10 05:28:26
Modify Date: 2024-01-12 11:59:19
Vitisin A has antioxidative, anticancer, antiapoptotic, neuroprotective and anti-inflammatory effects. Vitisin A inhibits LPS-induced NO and iNOS production via down-regulation of ERK1/2 and p38 and the NF-κB signal pathway. Vitisin A also inhibits adipocyte differentiation. Vitisin A is a resveratrol tetramer that can be isolated from Vitis vinifera roots[1][2][3].

Name	(+)-vitisin A
Synonyms	vitisin A Vitisin A (1S,6R,7S,11bS)-6-(5-{(E)-2-[(2S,3S)-3-(3,5-Dihydroxy-phenyl)-6-hydroxy-2-(4-hydroxy-phenyl)-2,3-dihydro-benzofuran-4-yl]-vinyl}-2-hydroxy-phenyl)-1,7-bis-(4-hydroxy-phenyl)-1,6,7,11b-tetrahydro-2-oxa-dibenzo[cd,h]azulene-4,8,10-triol

Description	Vitisin A has antioxidative, anticancer, antiapoptotic, neuroprotective and anti-inflammatory effects. Vitisin A inhibits LPS-induced NO and iNOS production via down-regulation of ERK1/2 and p38 and the NF-κB signal pathway. Vitisin A also inhibits adipocyte differentiation. Vitisin A is a resveratrol tetramer that can be isolated from Vitis vinifera roots[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
References	[1]. Mi Jeong Sung, et al. Vitisin A suppresses LPS-induced NO production by inhibiting ERK, p38, and NF-kappaB activation in RAW 264.7 cells. Int Immunopharmacol. 2009 Mar;9(3):319-23. [2]. Kim SH, et al. Vitisin A inhibits adipocyte differentiation through cell cycle arrest in 3T3-L1 cells. Biochem Biophys Res Commun. 2008 Jul 18;372(1):108-13. [3]. Choi J, et al. The central administration of vitisin a, extracted from Vitis vinifera, improves cognitive function and related signaling pathways in a scopolamine-induced dementia model. Biomed Pharmacother. 2023 Jul;163:114812.