Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Isocryptotanshinone
Price: ￥4418.0/5mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Isocryptotanshinone
Price: $950.0/100mg $1900.0/250mg $3800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: (8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

22550-15-8

22550-15-8 structure

22550-15-8 structure

Name: Isocryptotanshinone
Chemical Name: Isocryptotanshinon
CAS Number: 22550-15-8
Molecular Formula: C₁₉H₂₀O₃
Molecular Weight: 296.36000
Catalog: Signaling Pathways JAK/STAT Signaling STAT
Create Date: 2018-06-27 20:06:45
Modify Date: 2024-01-01 19:10:00
Isocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B.

Name	Isocryptotanshinon
Synonyms	4,4,8-Trimethyl-2,3,8,9-tetrahydro-1H,4H-10-oxa-cyclopenta[b]phenanthrene-7,11-dione

Description	Isocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer
Target	STAT3 PTP1B:56.1 μM (IC50)
In Vitro	It is showed that tanshinones significantly inhibited A549 proliferation and Isocryptotanshinone (ICTS) exhibits the strongest activity. Isocryptotanshinone inhibits the constitutive STAT3 and p-STAT3 (Y705) expression in concentration and time-dependent manners. Isocryptotanshinone dramatically inhibits the IL-6-stimulated expression of p-STAT3 (Y705) in a time-dependent manner[1].
References	[1]. Guo S, et al. Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells. J Drug Target. 2016 Dec;24(10):934-942. [2]. Han YM, et al. PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza. Biol Pharm Bull. 2005 Sep;28(9):1795-7.

Molecular Formula	C₁₉H₂₀O₃
Molecular Weight	296.36000
Exact Mass	296.14100
PSA	43.37000
LogP	3.59990

Hazard Codes	Xi