1133712-96-5

1133712-96-5 structure

Name: Letrozole-d4
Chemical Name: 4-((4-cyanophenyl)(1H-1,2,4-triazol-1-yl)methyl)benzonitrile-2,3,5,6-d4
CAS Number: 1133712-96-5
Molecular Formula: C₁₇H₇D₄N₅
Molecular Weight: 289.32700
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-01-12 21:19:26
Modify Date: 2024-02-07 11:23:13
Letrozole-d4 (CGS 20267-d4) is the deuterium labeled Letrozole. Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer[1][2][3].

Name	4-((4-cyanophenyl)(1H-1,2,4-triazol-1-yl)methyl)benzonitrile-2,3,5,6-d4

Description	Letrozole-d4 (CGS 20267-d4) is the deuterium labeled Letrozole. Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Others >> Aromatase
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Bhatnagar AS, et, al. Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J Steroid Biochem Mol Biol. 1990 Dec 20;37(6):1021-7. [3]. Mitropoulou TN, et, al. Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells. Int J Cancer. 2003 Mar 20;104(2):155-60. [4]. Schieweck K, et, al. Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen-dependent rat mammary tumors. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):633-6.

Melting Point	178-181 °C
Molecular Formula	C₁₇H₇D₄N₅
Molecular Weight	289.32700
Exact Mass	289.12700
PSA	78.29000
LogP	2.65916

Hazard Codes	Xi

1133712-96-5	1644566-39-1
112809-51-5	112809-52-6
2469244-77-5	1189805-15-9
1131981-29-7	1185179-33-2
1185240-22-5	1184263-99-7