331458-02-7

331458-02-7 structure

Name: CFM-4
Chemical Name: 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro[indoline-3,2'-[1.3.4]thiadiazol]-2-one
CAS Number: 331458-02-7
Molecular Formula: C₂₂H₁₆ClN₃OS
Molecular Weight: 405.90
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-05-15 15:33:32
Modify Date: 2025-09-21 12:27:23
CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells[1].

Name	1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro[indoline-3,2'-[1.3.4]thiadiazol]-2-one
Synonyms	CFM-4 L-703,664 succinate

Description	CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286(44):38000-38017.