147396-10-9

147396-10-9 structure

Name: Endotoxin Inhibitor
Chemical Name: h-lys-thr-lys-cys-lys-phe-leu-lys-lys-cys-oh
CAS Number: 147396-10-9
Molecular Formula: C₅₅H₉₇N₁₅O₁₂S₂
Molecular Weight: 1224.58000
Catalog: Research Areas Infection
Create Date: 2018-12-26 12:11:10
Modify Date: 2025-08-25 18:37:57
Endotoxin inhibitor a synthetic peptide that binds lipid A with high affinity, thereby detoxifying LPS (HY-D1056) and preventing LPS-induced cytokine release in vivo. Endotoxin inhibitor inhibits the febrile response to LPS with very low toxicity and lethality[1].

Name	h-lys-thr-lys-cys-lys-phe-leu-lys-lys-cys-oh
Synonyms	k-t-k-c-k-f-l-k-k-c lys-thr-lys-cys-lys-phe-leu-lys-lys-cys endotoxin inhibitor

Description	Endotoxin inhibitor a synthetic peptide that binds lipid A with high affinity, thereby detoxifying LPS (HY-D1056) and preventing LPS-induced cytokine release in vivo. Endotoxin inhibitor inhibits the febrile response to LPS with very low toxicity and lethality[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
In Vivo	Endotoxin inhibitor (i.p., 0.5 mg/kg) 可以显著减弱热暴露引起的 IL-1β、COX-2、IκB-β 和 LPS 活性的 mRNA 增加，以及在老年大鼠中热暴露引起的低体温和血浆 ACTH 和儿茶酚胺反应作用[1]。
References	[1]. Toshihiko Katafuchi, et al. Endotoxin inhibitor blocks heat exposure-induced expression of brain cytokine mRNA in aged rats. Brain Res Mol Brain Res. 2003 Oct 21;118(1-2):24-32.