133876-92-3
133876-92-3 structure
- Name: Nattokinase
- Chemical Name: Nattokinase
- CAS Number: 133876-92-3
- Molecular Formula: C20H23BCl2N2O9
- Molecular Weight: 517.122
- Catalog: Biochemical Plant extracts
- Create Date: 2018-03-06 08:00:00
- Modify Date: 2024-01-02 18:11:49
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Nattokinase is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases[1].
| Name | Nattokinase |
|---|---|
| Synonyms |
4-(Carboxymethyl)-2-[(1R)-1-{[N-(2,5-dichlorobenzoyl)glycyl]amino}-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
1,3,2-Dioxaborinane-4-acetic acid, 4-carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo- Nattoesse Haruno-Ogawa |
| Description | Nattokinase is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Nattokinase dissolves 94% blood clot at ten minutes and degrades the fibrin clot after two hours of incubation[2]. |
| In Vivo | Nattokinase (150-250 mg/kg; oral gavage twice daily for 2 days) exhibits fibrinolytic activity and dissolves blood clots in vivo[3]. Animal Model: Sprague-Dawley (SD) rats (180-220 g) are injected κ-Carrageenan[3] Dosage: 150, 250 mg/kg Administration: Oral gavage twice daily for 2 days Result: Increased the plasma concentration of fibrin/fibrinogen degradation products (FDPs) and D-Dimer in a dose-dependent manner. Decreased the fraction of the vessel cross section occupied by thrombosis. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H23BCl2N2O9 |
| Molecular Weight | 517.122 |
| Exact Mass | 516.087341 |
| Index of Refraction | 1.580 |