864750-70-9
864750-70-9 structure
- Name: revefenacin
- Chemical Name: Revefenacin
- CAS Number: 864750-70-9
- Molecular Formula: C35H43N5O4
- Molecular Weight: 597.747
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2018-09-14 14:16:00
- Modify Date: 2025-08-26 18:51:49
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Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a Ki of 0.18 nM
| Name | Revefenacin |
|---|---|
| Synonyms |
UNII:G2AE2VE07O
1-{2-[{4-[(4-Carbamoyl-1-piperidinyl)methyl]benzoyl}(methyl)amino]ethyl}-4-piperidinyl 2-biphenylylcarbamate TD-4208 1-(2-(3-((4-carbamoylpiperidin-1-yl)methyl)-N-methylbenzamido)ethyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate revefenacin Carbamic acid, N-[1,1'-biphenyl]-2-yl-, 1-[2-[[4-[[4-(aminocarbonyl)-1-piperidinyl]methyl]benzoyl]methylamino]ethyl]-4-piperidinyl ester |
| Description | Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a Ki of 0.18 nM |
|---|---|
| Related Catalog | |
| Target |
Ki: 0.42 nM (M1), 0.32 nM (M2), 0.18 nM (M3), 0.56 nM (M4), 6.7 nM (M5)[1] |
| In Vitro | The Kis of revefenacin are 0.42, 0.32, 0.18, 0.56, and 6.7 nM at human M1, M2, M3, M4 and M5 receptors, respectively. In a functional assay, revefenacin is shown to be a functional antagonist with inhibition constants similar to binding Ki's. Revefenacin also inhibits agonist-induced contraction of guinea pig isolated tracheal ring preparation with an affinity of 0.1 nM, similar to the measured M3 biding Ki[1]. |
| In Vivo | In anesthetized dogs, revefenacin, along with tiotropium and glycopyrronium, produce sustained inhibition of acetylcholine-induced bronchoconstriction for up to 24 hours. In anesthetized rats, inhaled revefenacin exhibits dose-dependent 24-hour bronchoprotection against methacholine-induced bronchoconstriction. The estimated 24-hour potency is 45.0 µg/mL and the bronchoprotective potencies are maintained after 7 days of once-daily dosing[2]. |
| Animal Admin | Rats: To determine the bronchoprotective and antisialagogue potency after a single dose, rats are exposed by inhalation to a nebulized solution of revefenacin (3–3000 µg/mL), tiotropium (0.3–300 µg/mL), glycopyrronium (1–1000 µg/mL), or vehicle (sterile water). Bronchoprotective activity is assessed 24 hours postdose. For the antisialagogue effect, inhibition of Pilo is assessed 1, 6, or 12 hours after inhalation of an efficacious dose of test compound to determine the time point at which peak effect occurred. All subsequent doses are measured at this time point[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 777.5±60.0 °C at 760 mmHg |
| Molecular Formula | C35H43N5O4 |
| Molecular Weight | 597.747 |
| Flash Point | 424.0±32.9 °C |
| Exact Mass | 597.331482 |
| LogP | 3.22 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.645 |
| Storage condition | -20℃ |