79103-90-5

79103-90-5 structure

Name: Polygalasaponin XXXI
Chemical Name: onjisaponin F
CAS Number: 79103-90-5
Molecular Formula: C₇₅H₁₁₂O₃₆
Molecular Weight: 1589.670
Catalog: Signaling Pathways Anti-infection Influenza Virus
Create Date: 2018-03-14 08:00:00
Modify Date: 2024-01-02 16:18:55
Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection[1].

Name	onjisaponin F
Synonyms	Polygalasaponin XXXI β-D-Galactopyranose, O-α-L-arabinopyranosyl-(1->3)-O-α-D-xylopyranosyl-(1->4)-O-6-deoxy-3-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)-2-furanyl]-α-L-mannopyranosyl-(1->2)-6 -deoxy-1-O-[(2β,3β)-3-(β-D-glucopyranosyloxy)-2,24,27-trihydroxy-24,28-dioxoolean-12-en-28-yl]-4-O-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]- α-L-Arabinopyranosyl-(1->3)-α-D-xylopyranosyl-(1->4)-6-deoxy-3-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-α-L-mannopyranosyl-(1->2)-6-deoxy-1-O-[(2β,3β)-3-(be ta-D-glucopyranosyloxy)-2,24,27-trihydroxy-24,28-dioxoolean-12-en-28-yl]-4-O-[(2E)-3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-β-D-galactopyranose

Description	Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection
In Vitro	Polygalasaponin XXXI (Onjisaponin F) also enhances anti-HA IgA and IgG Ab titers in the nasal wash, whereas Onjisaponins E and G enhances only anti-HA IgA Ab titer significantly. Polygalasaponin XXXI can induce protective immunity against intranasal infection by influenza virus[1]. Polygalasaponin XXXI (Onjisaponin F) (1 or 10 µg/mL) also induces ChAT mRNA level in rat basal forebrain cells[2].
In Vivo	Intranasal vaccination with Polygalasaponin XXXI (Onjisaponin F) inhibits proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice[1].
References	[1]. T Nagai, et al. Onjisaponins, From the Root of Polygala Tenuifolia Willdenow, as Effective Adjuvants for Nasal Influenza and Diphtheria-Pertussis-Tetanus Vaccines. Vaccine. 2001 Sep 14;19(32):4824-34. [2]. T Yabe, et al. Induction of NGF Synthesis in Astrocytes by Onjisaponins of Polygala Tenuifolia, Constituents of Kampo (Japanese Herbal) Medicine, Ninjin-yoei-to. Phytomedicine. 2003 Mar;10(2-3):106-14.