111869-49-9

111869-49-9 structure

Name: 7-Deaza-ddG
Chemical Name: 2-amino-7-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-one
CAS Number: 111869-49-9
Molecular Formula: C₁₁H₁₄N₄O₃
Molecular Weight: 250.257
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2016-03-23 22:24:28
Modify Date: 2024-01-09 01:10:58
7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) is a 2′,3′-dideoxynucleoside 5′-triphosphate, which can inhibit HIV-1 reverse transcriptase with a Ki of 25 nM[1].

Name	2-amino-7-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-one
Synonyms	MFCD07778654 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-3,7-dihydro-7-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]- 2-Amino-7-[(2R,5S)-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Description	7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) is a 2′,3′-dideoxynucleoside 5′-triphosphate, which can inhibit HIV-1 reverse transcriptase with a Ki of 25 nM[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1
References	[1]. Nicholas A Boyle, et al. Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase. J Med Chem. 2005 Apr 7;48(7):2695-700.