124888-22-8

124888-22-8 structure

Name: syringomycin E
Chemical Name: syringomycin E
CAS Number: 124888-22-8
Molecular Formula: C₅₃H₈₅ClN₁₄O₁₇
Molecular Weight: 1225.78000
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2017-02-08 08:53:08
Modify Date: 2025-08-27 16:06:44
Syringomycin E is an antifungal cyclic lipodepsinonapeptide. Syringomycin E exhibits growth inhibition of Saccharomyces cerevisiae through interaction with the plasma membrane. Syringomycin E causes K+ efflux, Ca2+ influx, and changes in membrane potential, and is related to channel formation[1][2].

Name	syringomycin E
Synonyms	SYRINGOMYCIN E FROM PSEUDOMONAS SYRINGAE B-301D syringomycin-E

Description	Syringomycin E is an antifungal cyclic lipodepsinonapeptide. Syringomycin E exhibits growth inhibition of Saccharomyces cerevisiae through interaction with the plasma membrane. Syringomycin E causes K+ efflux, Ca2+ influx, and changes in membrane potential, and is related to channel formation[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Syringomycin E (0.5 μg/mL, 1 μg/mL; 48 h) 对酿酒酵母菌株 SS33 和 SS56 有抑制作用[1]。 Syringomycin E 是一种离子通道型，对电势跨膜分布的变化敏感[2]。
References	[1]. Stock SD, et al. Syringomycin E inhibition of Saccharomyces cerevisiae: requirement for biosynthesis of sphingolipids with very-long-chain fatty acids and mannose- and phosphoinositol-containing head groups. Antimicrob Agents Chemother. 2000 May;44(5):1174-80. [2]. Efimova SS, et al. Alkaloids Modulate the Functioning of Ion Channels Produced by Antimicrobial Agents via an Influence on the Lipid Host. Front Cell Dev Biol. 2020 Jun 30;8:537.

Personal Protective Equipment	Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
RIDADR	NONH for all modes of transport