DC Chemicals Limited
China
Product Name: AC-93253 iodide
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
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Nanjing Peptide Biotech Ltd
China
Product Name: ac-93253 iodide
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: AC-93253 IODIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

108527-83-9

108527-83-9 structure

108527-83-9 structure

Name: ac-93253 iodide
Chemical Name: ac-93253 iodide
CAS Number: 108527-83-9
Molecular Formula: C₂₃H₂₅IN₂S
Molecular Weight: 488.42700
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2017-08-25 03:13:54
Modify Date: 2024-01-16 16:23:24
AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors[1].

Name	ac-93253 iodide

Description	AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Target	SIRT1:45.3 μM (IC50) SIRT2:6 μM (IC50) SIRT3:24.6 μM (IC50)
In Vitro	AC93253 可抑制 SIRT1、SIRT2 和 SIRT3，IC50 值分别为 45.3 μM、6 μM 和 24.6 μM[1]。 AC-93253（0、2、5、10 μM；16 h）显著增强微管蛋白、p53 和组蛋白 H4 的乙酰化[1]。 AC-93253 对四种肿瘤细胞系表现出选择性细胞毒性，IC50 值范围为 10 - 100 nM[1]。 AC-93253 显著触发细胞凋亡[1]。 Western Blot Analysis[1] Cell Line: NCI-H460 cells, HeLa cells Concentration: 0, 2, 5, 10 μM Incubation Time: 16 h Result: Increased the acetylation levels of a-tubulin in a dose-dependent manner. Increased the level of histone protein and p53.
References	[1]. Zhang, Yingjia et al. Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity. Biochemical and biophysical research communications vol. 386,4 (2009): 729-33.

Molecular Formula	C₂₃H₂₅IN₂S
Molecular Weight	488.42700
Exact Mass	488.07800
PSA	35.36000
LogP	2.60240

RIDADR	NONH for all modes of transport

5418-63-3 structure

5418-63-3

35080-47-8 structure

35080-47-8

~%

108527-83-9 structure

108527-83-9

Literature: Hamer et al. Journal of the Chemical Society, 1948 , p. 1872,887

Precursor 2
5418-63-3 35080-47-8
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