1670-87-7

1670-87-7 structure

Name: SD-169
Chemical Name: 1H-Indole-5-carboxamide
CAS Number: 1670-87-7
Molecular Formula: C₉H₈N₂O
Molecular Weight: 160.173
Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
Create Date: 2018-02-10 08:00:00
Modify Date: 2024-01-07 10:33:17
SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation[1].

Name	1H-Indole-5-carboxamide
Synonyms	1H-Indole-5-carboxamide indole-5-carboxamide

Description	SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Metabolic Disease
Target	p38α MAPK:3.2 nM (IC50) p38β MAPK:122 nM (IC50)
In Vitro	SD-169 significantly reduces p38 and HSP60 expression in T cells of the pancreatic beta islets[1]. SD-169 demonstrates 38-fold potency against p38α MAP kinase (IC50=3.2 nM) than p38β MAP kinase (IC50=122 nM)[1].
References	[1]. Medicherla S, et al. Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J Pharmacol Exp Ther. 2006 Jul;318(1):99-107.

Density	1.3±0.1 g/cm3
Boiling Point	457.6±18.0 °C at 760 mmHg
Melting Point	159-163ºC
Molecular Formula	C₉H₈N₂O
Molecular Weight	160.173
Flash Point	230.6±21.2 °C
Exact Mass	160.063660
PSA	58.88000
LogP	0.88
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.717

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport
HS Code	2933990090

1670-81-1

~72%

1670-87-7

Literature: LG LIFE SCIENCES LTD.; CHOI, Sung Pil; KIM, Geun Tae; SONG, Jeong Uk; KIM, Tae Hun; LIM, Dong Chul; KANG, Seung Wan; KIM, Hyung Jin Patent: WO2010/93191 A2, 2010 ; Location in patent: Paragraph 376-380 ; WO 2010/093191 A2

10075-50-0

18169-72-7

1670-87-7

Literature: Heterocycles, , vol. 34, # 6 p. 1169 - 1175

Precursor 3
1670-81-1 10075-50-0 18169-72-7
DownStream 1
114948-09-3

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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