147776-06-5
147776-06-5 structure
- Name: L-161,982
- Chemical Name: N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methylthiophene-2-carboxamide
- CAS Number: 147776-06-5
- Molecular Formula: C32H29F3N4O4S2
- Molecular Weight: 654.72200
- Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
- Create Date: 2016-05-29 13:46:25
- Modify Date: 2025-08-24 21:12:06
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L-161982 is a selective EP4 receptor antagonist. L-161982 completely blocks PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 alleviates collagen-induced arthritis in mice[1][2].
| Name | N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methylthiophene-2-carboxamide |
|---|---|
| Synonyms |
L-161,982
HMS3269M17 Peroxy Orange 1 |
| Description | L-161982 is a selective EP4 receptor antagonist. L-161982 completely blocks PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 alleviates collagen-induced arthritis in mice[1][2]. |
|---|---|
| Related Catalog | |
| Target |
EP4 |
| In Vitro | L-161982 (10 μM; 2 hours) blocks PGE2-stimulated cell proliferation of HCA-7 cells[1]. L-161982 (10 μM; 1 hour) blocks PGE2-stimulated ERK phosphorylation in HCA-7 cells[1]. L-161982 induces apoptosis, cell cycle arrest, and inhibits prostaglandin E2-induced proliferation in oral squamous carcinoma Tca8113 cells[3]. Cell Proliferation Assay[1] Cell Line: HCA-7 cells Concentration: 10 μM Incubation Time: 2 hours Result: Blocked PGE2-induced cell proliferation. |
| In Vivo | L-161982 (5 mg/kg; i.p.; once per day for 2 weeks) reduces arthritis lesions and lesion progression in CIA mice[2]. Animal Model: Female DBA/1 mice of 6 to 8 weeks old (collagen-induced arthritis (CIA) mice model)[1] Dosage: 5 mg/kg Administration: i.p.; once per day for 2 weeks Result: Showed less joint swelling and lower arthritis score after 35 days post immunization. |
| References |
| Density | 1.37g/cm3 |
|---|---|
| Melting Point | > 145 °C |
| Molecular Formula | C32H29F3N4O4S2 |
| Molecular Weight | 654.72200 |
| Exact Mass | 654.15800 |
| PSA | 139.68000 |
| LogP | 8.07100 |
| Index of Refraction | 1.633 |
| Storage condition | 2-8°C |
| RIDADR | NONH for all modes of transport |
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