DC Chemicals Limited
China
Product Name: Epoxomicin
Price: $650.0/50mg $1000.0/100mg $1800.0/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

134381-21-8

134381-21-8 structure

134381-21-8 structure

Name: Epoxomicin
Chemical Name: Epoxomicin
CAS Number: 134381-21-8
Molecular Formula: C₂₈H₅₀N₄O₇
Molecular Weight: 554.719
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2017-06-03 02:36:52
Modify Date: 2024-01-13 20:36:13
Epoxomicin is a cell-permeable and irreversible proteasome inhibitor, primarily the chymotrypsin-like activity.

Name	Epoxomicin
Synonyms	S7038,BU-4061T Epoxomicin (BU-4061T) (2S,3S)-2-[[(2S,3S)-2-[acetyl(methyl)amino]-3-methylpentanoyl]amino]-N-[(2S,3R)-3-hydroxy-2-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]butanoyl]-3-methylpentanamide Epoxomicin N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-1-oxo-2-pentanyl}-L-threoninamide L-Threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-

Description	Epoxomicin is a cell-permeable and irreversible proteasome inhibitor, primarily the chymotrypsin-like activity.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Research Areas >> Cancer Natural Products >> Others
References	[1]. Kim KB, et al. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3335-40. [2]. Hanada M, et al. Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo). 1992 Nov;45(11):1746-52. [3]. Garrett IR, et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest. 2003 Jun;111(11):1771-82. [4]. McNaught KS, et al. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol. 2004 Jul;56(1):149-62. [5]. Rideout HJ, et al. Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition. J Neurochem. 2005 Jun;93(5):1304-13.

Density	1.1±0.1 g/cm3
Boiling Point	795.7±60.0 °C at 760 mmHg
Melting Point	107-109ºC
Molecular Formula	C₂₈H₅₀N₄O₇
Molecular Weight	554.719
Flash Point	435.0±32.9 °C
Exact Mass	554.367920
PSA	157.44000
LogP	3.32
Vapour Pressure	0.0±6.3 mmHg at 25°C
Index of Refraction	1.504
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport