136259-20-6

136259-20-6 structure

Name: P32/98
Chemical Name: 2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)pentan-1-one,but-2-enedioic acid
CAS Number: 136259-20-6
Molecular Formula: C₂₂H₄₀N₄O₆S₂
Molecular Weight: 520.70600
Catalog: Signaling Pathways Metabolic Enzyme/Protease Dipeptidyl Peptidase
Create Date: 2018-12-28 11:51:02
Modify Date: 2025-08-25 13:48:04
P32/98 is a potent inhibitor of dipeptidyl peptidase IV. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in preclinical studies using the fatty Zucker rat, an animal model for IGT (impaired glucose tolerance)[1].

Name	2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)pentan-1-one,but-2-enedioic acid
Synonyms	P32/98 L-threo-isoleucyl thiazolidine isoleucine thiazolide L-threo-isoleucyl rhiazolidine

Description	P32/98 is a potent inhibitor of dipeptidyl peptidase IV. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in preclinical studies using the fatty Zucker rat, an animal model for IGT (impaired glucose tolerance)[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase Research Areas >> Metabolic Disease
Target	DPP4[1]
In Vivo	P32/98 (25 mg/kg; i.g.; once daily) long-time treatment significantly improves the glucose tolerance in Zucker diabetic fatty rats[2]. Animal Model: Zucker diabetic fatty rat[2] Dosage: 25 mg/kg Administration: i.g., once daily Result: Significantly improved the glucose tolerance in Zucker diabetic fatty rats.
References	[1]. Augstein P, et al. Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance. Diabetes Obes Metab. 2008;10(10):850-861. [2]. Wargent E, et al. Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone. Diabetes Obes Metab. 2005;7(2):170-181.