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16679-58-6

16679-58-6 structure
16679-58-6 structure
  • Name: (Deamino-Cys1,D-Arg8)-Vasopressin acetate salt
  • Chemical Name: desmopressin
  • CAS Number: 16679-58-6
  • Molecular Formula: C46H64N14O12S2
  • Molecular Weight: 1069.217
  • Catalog: API Urinary system medication Diabetes insipidus medication
  • Create Date: 2018-08-03 09:34:20
  • Modify Date: 2024-01-02 17:31:23
  • Desmopressin(DDAVP) is the synthetic analogue of the antidiuretic hormone arginine vasopressin. IC50 Value:Target: Vasopressin ReceptorThe antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin works by limiting the amount of water that is eliminated in the urine. Desmopressin binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates release of von Willebrand factor from endothelial cells by acting on the V2 receptor.

Name desmopressin
Synonyms DESAMINO-[D-ARG8]VASOPRESSIN
Desmopressin
Glycinamide, 1-[[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-4-yl]carbonyl]-L-prolyl-L-arginyl-
DDAVP
DESMOPRESSIN,HUMAN
Mep(mercaptopropionic acid)-YFQNCPdRG-NH2
DDAVP,HUMAN
[DEAMINO1,DARG8] VASOPRESSIN
M.W. 1069.22 C46H64N14O12S2
DESMOPRESSIN ACETATE PH. EUR.
[DEAMINO-CYS1,D-ARG8]-VASOPRESSIN
Adiuretin-SD
1-{[(4R,7S,10S,13S,16S)-7-(2-Amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-arginylglycinamide
Octostim
MINIRIN
MAP-TYR-PHE-GLN-ASN-CYS-PRO-D-ARG-GLY-NH2(DISULFIDE BRIDGE,MAP1-CYS6)
Description Desmopressin(DDAVP) is the synthetic analogue of the antidiuretic hormone arginine vasopressin. IC50 Value:Target: Vasopressin ReceptorThe antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin works by limiting the amount of water that is eliminated in the urine. Desmopressin binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates release of von Willebrand factor from endothelial cells by acting on the V2 receptor.
Related Catalog
References

[1]. Vande Walle J, Stockner M, Raes A, N?rgaard JP. Desmopressin 30 years in clinical use: a safety review. Curr Drug Saf. 2007 Sep;2(3):232-8.

[2]. Franchini M, Zaffanello M, Lippi G. The use of desmopressin in mild hemophilia A. Blood Coagul Fibrinolysis. 2010 Oct;21(7):615-9.

[3]. Sánchez-Luceros A, Meschengieser SS, Woods AI et al. Biological and clinical response to desmopressin (DDAVP) in a retrospective cohort study of children with low von Willebrand factor levels and bleeding history. Thromb Haemost. 2010 Nov;104(5):984-9.

[4]. Alonso DF, Ripoll GV, Garona J et al. Metastasis: recent discoveries and novel perioperative treatment strategies with particular interest in the hemostatic compound desmopressin. Curr Pharm Biotechnol. 2011 Nov;12(11):1974-80.

[5]. Tsukamoto I. Recent patenting activities in the discovery and development of vasopressin V2 receptor agonists. Expert Opin Ther Pat. 2012 Jun;22(6):579-86.

Density 1.6±0.1 g/cm3
Molecular Formula C46H64N14O12S2
Molecular Weight 1069.217
Exact Mass 1068.427002
PSA 486.01000
LogP -5.82
Index of Refraction 1.713
HS Code 2937190090
HS Code 2937190090