CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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GE5925000
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CHEMICAL NAME :
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C.I. Solvent Yellow 33
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CAS REGISTRY NUMBER :
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8003-22-3
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LAST UPDATED :
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199712
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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5 gm/kg
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TOXIC EFFECTS :
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Gastrointestinal - other changes
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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>2 gm/kg
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Liver - other changes Kidney, Ureter, Bladder - other changes
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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345 mg/kg/14D-C
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TOXIC EFFECTS :
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Liver - changes in liver weight
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2243 mg/kg/13W-C
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TOXIC EFFECTS :
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Liver - changes in liver weight
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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230 mg/m3/6H/4W-I
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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100 mg/m3/6H/13W-I
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TOXIC EFFECTS :
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Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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828 mg/kg/14D-C
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TOXIC EFFECTS :
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Liver - changes in liver weight
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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5384 mg/kg/13W-C
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TOXIC EFFECTS :
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Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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67 gm/kg
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SEX/DURATION :
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female 4 week(s) pre-mating female 1-21 day(s) after conception lactating female 4 week(s) post-birth
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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73570 mg/kg
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SEX/DURATION :
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multigeneration
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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5384 mg/kg
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SEX/DURATION :
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male 13 week(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
MUTATION DATA
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TYPE OF TEST :
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Mutation in mammalian somatic cells
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TEST SYSTEM :
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Rodent - mouse Lymphocyte
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DOSE/DURATION :
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15 mg/L
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REFERENCE :
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EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12,219,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3135 No. of Facilities: 149 (estimated) No. of Industries: 3 No. of Occupations: 12 No. of Employees: 2406 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3135 No. of Facilities: 1501 (estimated) No. of Industries: 7 No. of Occupations: 12 No. of Employees: 14314 (estimated) No. of Female Employees: 4310 (estimated)
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