CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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VV2710000
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CHEMICAL NAME :
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Silane, chlorotrimethyl-
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CAS REGISTRY NUMBER :
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75-77-4
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BEILSTEIN REFERENCE NO. :
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1209232
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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13
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MOLECULAR FORMULA :
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C3-H9-Cl-Si
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MOLECULAR WEIGHT :
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108.66
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WISWESSER LINE NOTATION :
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G-SI-1&1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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5660 uL/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - other changes
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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100 mg/m3
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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750 mg/kg
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TOXIC EFFECTS :
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Immunological Including Allergic - decreased immune response
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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1780 uL/kg
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TOXIC EFFECTS :
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Behavioral - altered sleep time (including change in righting reflex) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1000 mg/kg/I
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
MUTATION DATA
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TYPE OF TEST :
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Mutation in microorganisms
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TEST SYSTEM :
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Bacteria - Salmonella typhimurium
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DOSE/DURATION :
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1 mg/plate
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REFERENCE :
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ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl 7),1,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83272 No. of Facilities: 59 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 200 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83272 No. of Facilities: 8 (estimated) No. of Industries: 2 No. of Occupations: 15 No. of Employees: 1876 (estimated) No. of Female Employees: 20 (estimated)
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