DC Chemicals Limited
China
Product Name: FLI-06
Price: $350.0/100mg $700.0/250mg $1400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

313967-18-9

313967-18-9 structure

313967-18-9 structure

Name: FLI-06
Chemical Name: 3-Quinolinecarboxylic acid, 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-, cyclohexyl ester
CAS Number: 313967-18-9
Molecular Formula: C₂₅H₃₀N₂O₅
Molecular Weight: 438.516
Catalog: Biochemical Inhibitor Proteases Gamma-secretase inhibitor
Create Date: 2018-12-28 09:39:45
Modify Date: 2024-01-02 17:37:31
FLI-06 is an inhibitor of Notch signaling with an EC50 of 2.3 μM.

Name	3-Quinolinecarboxylic acid, 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-, cyclohexyl ester
Synonyms	Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate FLI-06 1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester

Description	FLI-06 is an inhibitor of Notch signaling with an EC50 of 2.3 μM.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Notch Research Areas >> Cancer
Target	EC50: 2.3 μM (Notch signaling)[1]
In Vitro	FLI-06, disrupted the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. FLI-06 inhibited general secretion at a step before exit from the endoplasmic reticulum. In FLI-06–treated cells, no APPCTF accumulates despite strongly reduced Aβ secretion, suggesting that it acts upstream of α-secretase and β-secretase cleavage. FLI-06 is a very useful chemical probe to study the inhibition of membrane traffic at pre- ER-exit site (ERES) stages without fusion of ER-Golgi[1].
Kinase Assay	EC50 values of the test compounds are calculated from serial dilution series ranging from 200 to 0.1 μM. Cells are seeded in 96-well plates at a density of 5,000 cells per well in 100 μL medium. The next day, 100 μL medium containing each test compound is added. Cells are incubated for 16 h, fixed and processed for automated microscopy. EC50 estimates are calculated using four-parameter log-logistic fit with the package drc[1].
References	[1]. Kramer A, et al. Small molecules intercept Notch signaling and the early secretory pathway. Nat Chem Biol. 2013 Nov;9(11):731-8.

Density	1.3±0.1 g/cm3
Boiling Point	597.5±50.0 °C at 760 mmHg
Molecular Formula	C₂₅H₃₀N₂O₅
Molecular Weight	438.516
Flash Point	315.2±30.1 °C
Exact Mass	438.215485
PSA	101.22000
LogP	4.47
Appearance	white to beige
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.596
Storage condition	2-8°C
Water Solubility	DMSO: soluble5mg/mL, clear (warmed)

RIDADR	3077