Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-(4-((3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)benzoyl)glutamic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

118252-44-1

118252-44-1 structure

Name: N-(4-((3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)benzoyl)glutamic acid
Chemical Name: (2S)-2-[[4-[3-(2,6-diamino-4-oxo-1H-pyrimidin-5-yl)propylamino]benzoyl]amino]pentanedioic acid
CAS Number: 118252-44-1
Molecular Formula: C₁₉H₂₄N₆O₆
Molecular Weight: 432.43000
Catalog: Research Areas Cancer
Create Date: 2018-07-05 19:12:16
Modify Date: 2024-04-11 13:32:03
5-DACTHF (543U76) is an inhibitor of purine de novo biosynthesis. 5-DACTHF is a GAR-TFase and AICAR-TFase inhibitor (IC50: 3 and 94 μM). 5-DACTHF is a potent antitumor agent[1].

Name	(2S)-2-[[4-[3-(2,6-diamino-4-oxo-1H-pyrimidin-5-yl)propylamino]benzoyl]amino]pentanedioic acid
Synonyms	5-Deazacyclotetrahydrofolate n-(4-{[3-(2,6-diamino-4-oxo-1,4-dihydropyrimidin-5-yl)propyl]amino}benzoyl)-l-glutamic acid 543U76 5-DACTHF

Description	5-DACTHF (543U76) is an inhibitor of purine de novo biosynthesis. 5-DACTHF is a GAR-TFase and AICAR-TFase inhibitor (IC50: 3 and 94 μM). 5-DACTHF is a potent antitumor agent[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Styles, V.L. Synthesis of the penta-glutamyl derivative of N-[4-[N-[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)-propyl]amino]benzoyl]-L-glutamic acid (5-DACTHF). An acyclic analogue of tetrahydrofolic acid. 1990. Journal of Heterocyclic Chemistry, 27: 1809-1813.