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480-68-2

480-68-2 structure
480-68-2 structure
  • Name: 5-Nitrobarbituric acid
  • Chemical Name: 5-Nitrobarbituric acid
  • CAS Number: 480-68-2
  • Molecular Formula: C4H3N3O5
  • Molecular Weight: 173.084
  • Catalog: Signaling Pathways Anti-infection HSV
  • Create Date: 2018-03-24 08:00:00
  • Modify Date: 2025-08-26 17:04:48
  • 5-Nitrobarbituric acid is a herpes simplex virus type-1 (HSV-1) inhibitor (IC50=1.7 μM)[1].
Name 5-Nitrobarbituric acid
Synonyms 5-nitro-2,4,6-pyrimidinetrione
EINECS 207-557-0
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-nitro-
5-Nitro-2,4,6(1H,3H,5H)-pyrimidinetrione
5-Nitrobarbituric Acid Trihydrate
NITROBARBITURIC ACID
AURORA KA-3829
5-nitro-barbituricaci
5-nitropyrimidine-2,4,6(1H,3H,5H)-trione
Dilituric Acid Trihydrate
5-Nitrobarbiuricacid
MFCD00006667
DILITURIC ACID
5-NITRO-2,4,6-TRIHYDROXYPYRIMIDINE
5-NitrobarbituricAcid
Description 5-Nitrobarbituric acid is a herpes simplex virus type-1 (HSV-1) inhibitor (IC50=1.7 μM)[1].
Related Catalog
Target

HSV-1:1.7 μM (IC50)

In Vitro 5-Nitrobarbituric acid can inhibit vero cell growth[1]. Cell Cytotoxicity Assay[1] Cell Line: Vero cells Concentration: 0.06-5 μM Incubation Time: 2 hours Result: Showed high cytotoxicity to vero cells.
References

[1]. J V de Julián-Ortiz, et al. Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds. J Med Chem. 1999 Aug 26;42(17):3308-14.
Density 1.8±0.1 g/cm3
Boiling Point 303.69°C
Melting Point 180.5°C
Molecular Formula C4H3N3O5
Molecular Weight 173.084
Exact Mass 173.007263
PSA 121.09000
LogP -1.13
Index of Refraction 1.581

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CQ7300000
CHEMICAL NAME :
Barbituric acid, 5-nitro-
CAS REGISTRY NUMBER :
480-68-2
BEILSTEIN REFERENCE NO. :
0180758
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C4-H3-N3-O5
MOLECULAR WEIGHT :
173.10
WISWESSER LINE NOTATION :
T6VMVMV FHJ FNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01678
Risk Phrases 36/37/38
Safety Phrases S26-S36/37/39
RTECS CQ7300000
HS Code 2933540000
67-52-7 structure

67-52-7

~98%

480-68-2 structure

480-68-2

Literature: Langlet, Abraham; Latypov, Nikolaj V.; Wellmar, Ulf; Goede, Patrick; Bergman, Jan Tetrahedron Letters, 2000 , vol. 41, # 12 p. 2011 - 2013
87-39-8 structure

87-39-8

~%

480-68-2 structure

480-68-2

Literature: Biltz; Sedlatschek Chemische Berichte, 1924 , vol. 57, p. 347
476-61-9 structure

476-61-9

~%

480-68-2 structure

480-68-2

Literature: Baeyer Justus Liebigs Annalen der Chemie, 1863 , vol. 127, p. 230 Justus Liebigs Annalen der Chemie, 1864 , vol. 130, p. 131 Full Text Show Details Schlieper Justus Liebigs Annalen der Chemie, 1845 , vol. 56, p. 24
67-52-7 structure

67-52-7

7697-37-2 structure

7697-37-2

~%

480-68-2 structure

480-68-2

Literature: Baeyer Justus Liebigs Annalen der Chemie, 1864 , vol. 130, p. 158 Chemische Berichte, 1875 , vol. 8, p. 613 Full Text Show Details Grimaux Bulletin de la Societe Chimique de France, 1879 , vol. <2> 31, p. 147 Annales de Chimie (Cachan, France), 1879 , vol. <5> 17, p. 279
409315-26-0 structure

409315-26-0

7697-37-2 structure

7697-37-2

~%

480-68-2 structure

480-68-2

Literature: v.Vogel Justus Liebigs Annalen der Chemie, 1901 , vol. 315, p. 260,264 Full Text Show Details Bartling Justus Liebigs Annalen der Chemie, 1905 , vol. 339, p. 37
7697-37-2 structure

7697-37-2

476-61-9 structure

476-61-9

~%

480-68-2 structure

480-68-2

Literature: Baeyer Justus Liebigs Annalen der Chemie, 1863 , vol. 127, p. 230 Justus Liebigs Annalen der Chemie, 1864 , vol. 130, p. 131 Full Text Show Details Schlieper Justus Liebigs Annalen der Chemie, 1845 , vol. 56, p. 24
7782-77-6 structure

7782-77-6

476-61-9 structure

476-61-9

~%

480-68-2 structure

480-68-2

Literature: Baeyer Justus Liebigs Annalen der Chemie, 1863 , vol. 127, p. 230 Justus Liebigs Annalen der Chemie, 1864 , vol. 130, p. 131 Full Text Show Details Schlieper Justus Liebigs Annalen der Chemie, 1845 , vol. 56, p. 24
243664-45-1 structure

243664-45-1

7697-37-2 structure

7697-37-2

~%

480-68-2 structure

480-68-2

Literature: Trzcinski Chemische Berichte, 1883 , vol. 16, p. 1058
73730-97-9 structure

73730-97-9

7732-18-5 structure

7732-18-5

~%

464-10-8 structure

464-10-8

480-68-2 structure

480-68-2

Detail
Literature: Biltz; Sedlatschek Chemische Berichte, 1924 , vol. 57, p. 347
HS Code 2933540000
Summary 2933540000 other derivatives of malonylurea (barbituric acid); salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%
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