1055970-47-2
1055970-47-2 structure
- Name: NAI
- Chemical Name: 3-(1H-imidazol-1-ylcarbonyl)-2-methylpyridine
- CAS Number: 1055970-47-2
- Molecular Formula: C10H9N3O
- Molecular Weight: 187.19800
- Catalog: Research Areas Others
- Create Date: 2016-06-14 23:10:49
- Modify Date: 2025-08-25 14:54:38
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2-Methylnicotinic acid imidazolide, a RNA-SHAPE electrophile, is a general cell-permeable probe of RNA structure. 2-Methylnicotinic acid imidazolide can probe RNA structure in vivo and in live cells with high accuracy and single-nucleotide resolution[1].
| Name | 3-(1H-imidazol-1-ylcarbonyl)-2-methylpyridine |
|---|
| Description | 2-Methylnicotinic acid imidazolide, a RNA-SHAPE electrophile, is a general cell-permeable probe of RNA structure. 2-Methylnicotinic acid imidazolide can probe RNA structure in vivo and in live cells with high accuracy and single-nucleotide resolution[1]. |
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| Related Catalog | |
| In Vitro | Application of 100 mM 2-Methylnicotinic acid imidazolide (NAI) to murine embryonic stem cells (ESCs) resulted in 5S rRNA modification in as little as one minute with suitable signal-to-noise ratio. This signal begins to plateau by 15 minutes. 2-Methylnicotinic acid imidazolide also modifies 5S rRNA in cultured human cancer cells, Drosophila S2 cells, yeast, and E. coli. 2-Methylnicotinic acid imidazolide can read out alterations in the RNA tertiary structure as a result of sampling critical mature ribosome conformations. |
| References |
[1]. Robert C Spitale, et al. RNA SHAPE analysis in living cells. Nat Chem Biol. 2013 Jan;9(1):18-20. |
| Molecular Formula | C10H9N3O |
|---|---|
| Molecular Weight | 187.19800 |
| Exact Mass | 187.07500 |
| PSA | 47.78000 |
| LogP | 1.27500 |
| Precursor 0 | |
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| DownStream 2 | |
