55319-36-3

55319-36-3 structure

Name: Soyasaponin II
Chemical Name: soyasaponin II
CAS Number: 55319-36-3
Molecular Formula: C₄₇H₇₆O₁₇
Molecular Weight: 913.09600
Catalog: Signaling Pathways Anti-infection CMV
Create Date: 2017-08-15 12:59:56
Modify Date: 2024-01-05 17:27:51
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure[1][2].

Name	soyasaponin II
Synonyms	MFCD04039836

Description	Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Signaling Pathways >> Anti-infection >> HSV Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> CMV
Target	HSV-1:54 μM (IC50) HIV-1:112 μM (IC50) influenza virus:88 μM (IC50) HCMV:104 μM (IC50) NLRP3 inflammasome
In Vitro	Soyasaponin II inhibits the replication of HSV-1 (IC50=54μM), HCMV (104μM), influenza virus (88μM), and HIV-1 (112 μM)[1].
In Vivo	Soyasaponin II (5 mg/kg; p.o.; once a day for three consecutive days) ameliorates canonical NLRP3 inflammasome-associated innate immune response[2].
References	[1]. Hayashi K, et al. Inhibitory activity of soyasaponin II on virus replication in vitro. Planta Med. 1997;63(2):102-105. [2]. Wang F, et al. Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice. Theranostics. 2020;10(6):2714-2726. Published 2020 Feb 3.

Hazard Codes	Xi