1247028-61-0

1247028-61-0 structure

Name: Necrocide 1
Chemical Name: (3S)-3-cycloheptyl-3-(4-hydroxyphenyl)-6-methoxy-7-methyl-1H-indol-2-one
CAS Number: 1247028-61-0
Molecular Formula: C₂₃H₂₇NO₃
Molecular Weight: 365.47
Catalog: Research Areas Cancer
Create Date: 2016-03-21 07:16:18
Modify Date: 2024-09-13 20:44:36
Necrocide 1 (compound (S)-38) a potent anticancer agent. Necrocide 1 has antiproliferative activity with an IC50 value of 0.48 and 2 nM for MCF-7 and PC3, respectively[1].

Name	(3S)-3-cycloheptyl-3-(4-hydroxyphenyl)-6-methoxy-7-methyl-1H-indol-2-one
Synonyms	2H-Indol-2-one,3-cycloheptyl-1,3-dihydro-3-(4-hydroxyphenyl)-6-methoxy-7-methyl-,(3S)

Description	Necrocide 1 (compound (S)-38) a potent anticancer agent. Necrocide 1 has antiproliferative activity with an IC50 value of 0.48 and 2 nM for MCF-7 and PC3, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Synthesis and Antitumor Effect in Vitro and in Vivo of Substituted 1,3-Dihydroindole-2-onesJ. Med. Chem., Article ASAPDOI: 10.1021/jm100763jPublication Date (Web): September 16, 2010 [2]. Christensen MK, et, al. Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones. J Med Chem. 2010 Oct 14;53(19):7140-5.