423735-93-7

423735-93-7 structure

Name: ML161
Chemical Name: 2-bromo-N-[3-(butanoylamino)phenyl]benzamide
CAS Number: 423735-93-7
Molecular Formula: C₁₇H₁₇BrN₂O₂
Molecular Weight: 361.233
Catalog: Signaling Pathways GPCR/G Protein Protease-Activated Receptor (PAR)
Create Date: 2017-09-05 10:45:53
Modify Date: 2024-01-10 06:36:28
Parmodulin 2 (ML161),a probe, is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC50 of 0.26 μM. Parmodulin 2 inhibits platelet aggregation induced by a PAR1 peptide agonist or by thrombin and has shown cytoprotective effects[1, 2].

Name	2-bromo-N-[3-(butanoylamino)phenyl]benzamide
Synonyms	2-Bromo-N-[3-(butyrylamino)phenyl]benzamide 2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]-benzamide Benzamide, 2-bromo-N-[3-[(1-oxobutyl)amino]phenyl]- Benzamide (2-bromo-N-[3-[(1-oxobutyl)amino]phenyl] ML 161

Description	Parmodulin 2 (ML161),a probe, is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC50 of 0.26 μM. Parmodulin 2 inhibits platelet aggregation induced by a PAR1 peptide agonist or by thrombin and has shown cytoprotective effects[1, 2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)
Target	PAR1[1]
References	[1]. Gandhi DM, et al. Characterization of Protease-Activated Receptor (PAR) ligands: Parmodulins are reversible allosteric inhibitors of PAR1-driven calcium mobilization in endothelial cells. Bioorg Med Chem. 2018 May 15;26(9):2514-2529. [2]. Dockendorff C Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1Receptor. ACS Med Chem Lett. 2012 Mar 8;3(3):232-237.

93469-29-5

88-65-3

~94%

423735-93-7

107829-09-4

423735-93-7

99-09-2

423735-93-7

Precursor 4
93469-29-5 88-65-3 107829-09-4 99-09-2
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%