54142-77-7

54142-77-7 structure

Name: 2-Keto-D-galactose
Chemical Name: 3,4,5,6-tetrahydroxy-2-oxohexanal
CAS Number: 54142-77-7
Molecular Formula: C₆H₁₀O₆
Molecular Weight: 178.14000
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2016-02-24 05:25:55
Modify Date: 2024-09-17 18:10:25
2-Keto-D-galactose (D-Galactosone) inhibits DNA synthesis, and inhibits proliferation of in vitro grown Ehrlich ascites tumor cells[1].

Name	3,4,5,6-tetrahydroxy-2-oxohexanal
Synonyms	D-arabino-hexos-2-ulose D-arabino-hexosulose D-glucosone arabino-hexos-2-ulose 3-deoxyglucosone 2-keto-D-glucose galactosone

Description	2-Keto-D-galactose (D-Galactosone) inhibits DNA synthesis, and inhibits proliferation of in vitro grown Ehrlich ascites tumor cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Target	DNA synthesis[1]
In Vitro	2 mM 2-Keto-D-galactose (Galactosone) causes a comparable inhibition of DNA synthesis. Proliferation of in vitro grown Ehrlich ascites tumor cells is completely inhibited by 1-2 mM 2-Keto-D-galactose without severely affecting viability (dye exclusion test); no phase-specific arrest of cell growth is observed[1].
References	[1]. Reiffen KA, et al. A comparative study on proliferation, macromolecular synthesis and energy metabolism of in vitro-grown Ehrlich ascites tumor cells in the presence of glucosone, galactosone and methylglyoxal. J Cancer Res Clin Oncol. 1984;107(3):206-10.