Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1H-Purine-2,6-dione,7-[2-(diethylamino)ethyl]-3,7-dihydro-1,3-dimethyl-
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314-35-2

314-35-2 structure

314-35-2 structure

Name: 7-[2-(Diethylamino)ethyl]-1,3-dimethylxanthine
Chemical Name: 7-[2-(Diethylamino)ethyl]-1,3-dimethylxanthine
CAS Number: 314-35-2
Molecular Formula: C₁₃H₂₁N₅O₂
Molecular Weight: 279.33800
Create Date: 2017-07-24 04:12:38
Modify Date: 2024-01-08 23:42:36

Name	7-[2-(Diethylamino)ethyl]-1,3-dimethylxanthine
Synonyms	Ditenate ETAFEDRINE 2-[ethyl(methyl)amino]-1-phenylpropan-1-ol hydrochloride(1:1) Etafedrine HCl Etafedrine hydrochloride [USAN] 7-(2-Diaethylamino-aethyl)-1,3-dimethyl-3,7-dihydro-purin-2,6-dion 2-N-ethyl-N-methylamino-1-phenylpropanol hydrochloride 7-(2-diethylamino-ethyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione Etafedrine hydrochloride etamiphylline Nethamine Nethamine (TN) Soluphylline 7-[2-(diethylamino)ethyl]theophylline Etafedrinhydrochlorid

Density	1.24g/cm3
Boiling Point	460.2ºC at 760mmHg
Molecular Formula	C₁₃H₂₁N₅O₂
Molecular Weight	279.33800
Flash Point	232.1ºC
Exact Mass	279.17000
PSA	65.06000
Index of Refraction	1.605

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH5095000

CHEMICAL NAME :: Theophylline, 7-(2-diethylamino)ethyl-

CAS REGISTRY NUMBER :: 314-35-2

BEILSTEIN REFERENCE NO. :: 0291098

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H21-N5-O2

MOLECULAR WEIGHT :: 279.39

WISWESSER LINE NOTATION :: T56 BN DN FNVNVJ B2N2&2 F1 H1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - olfactory nerve change Behavioral - convulsions or effect on seizure threshold Cardiac - change in rate

REFERENCE :: HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 9,201,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1237 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,343,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 254 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,343,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 182 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,649,1954

HS Code	2933990090

58-55-9 structure

58-55-9

100-35-6 structure

100-35-6

~82%

314-35-2 structure

314-35-2

Literature: Bram; Bensaid; Combet-Farnoux; et al. Pharmazie, 1986 , vol. 41, # 6 p. 431 - 432

Precursor 2
58-55-9 100-35-6
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%