79127-35-8

79127-35-8 structure

Name: Echinosporin
Chemical Name: 1,5-(epoxymethano)cyclopenta[c]pyran-3-carboxamide, 1,4a,5,7a-tetrahydro-5-hydroxy-8-oxo-, (1.α.,4a.β.,5.β.,7a.β.)-, (-)
CAS Number: 79127-35-8
Molecular Formula: C₁₀H₉NO₅
Molecular Weight: 223.18200
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2017-11-25 19:19:30
Modify Date: 2024-01-01 21:44:30
Echinosporin (XK-213) is an antibiotic. Echinosporin can be isolated from Amycolatopsis strain. Echinosporin has antifungal activity and antitumor activity[1][2].

Name	1,5-(epoxymethano)cyclopenta[c]pyran-3-carboxamide, 1,4a,5,7a-tetrahydro-5-hydroxy-8-oxo-, (1.α.,4a.β.,5.β.,7a.β.)-, (-)
Synonyms	echinosporine

Description	Echinosporin (XK-213) is an antibiotic. Echinosporin can be isolated from Amycolatopsis strain. Echinosporin has antifungal activity and antitumor activity[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Inflammation/Immunology
Target	MIC50: 64 μg/mL (Fusarium oxysporum); 64 μg/mL (Fusarium solani); 32 μg/mL (Alternaria panax); 64 μg/mL (Phoma herbarum)[2].
In Vitro	Echinosporin (XK-213) 对革兰氏阳性和阴性微生物表现出较弱的抗菌活性，并具有抗肿瘤活性[1]。 Echinosporin 对三七根腐病病原体具有抗真菌活性，包括 Fusarium oxysporum、Fusarium solani、Alternaria panax 和 Phoma herbarum，MIC50 值分别为 64、64、32 和 64 μg/mL[2]。
References	[1]. T Sato, et al. A new antibiotic echinosporin (XK-213) - producing organism, isolation and characterization. J Antibiot (Tokyo). 1982 Mar;35(3):266-71. [2]. Xindong Xu, et al. Echinosporin antibiotics isolated from Amycolatopsis strain and their antifungal activity against root-rot pathogens of the Panax notoginseng. Folia Microbiol (Praha). 2019 Mar;64(2):171-175.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 35,266,1982