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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,3,5-Triazine-2,4-diamine,1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-, hydrochloride (1:1)
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152-53-4

152-53-4 structure

152-53-4 structure

Name: Cycloguanil Hydrochloride
Chemical Name: 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine,hydrochloride
CAS Number: 152-53-4
Molecular Formula: C₁₁H₁₅Cl₂N₅
Molecular Weight: 288.17600
Catalog: Signaling Pathways Anti-infection Parasite
Create Date: 2018-12-20 15:20:40
Modify Date: 2024-01-03 08:15:51
Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].

Name	1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine,hydrochloride
Synonyms	1-(4-chloro-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diyldiamine,hydrochloride 4,6-diamino-1-(4'-chlorophenyl)-1,2-dihydro-2,2-dimethyl-1,3,5-triazine CYCLOGUANIL HYDROCHLORIDE BN 2410 Chloroguanide triazine hydrochloride 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride 1-(4-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1,3,5-TRIAZINE HCL 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine monohydrochloride 1-(4'-chlorophenyl)-2,2-dimethyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride 1-(4-Chlor-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazin-2,4-diyldiamin,Hydrochlorid

Description	Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200.

Boiling Point	400.7ºC at 760mmHg
Melting Point	210-215ºC
Molecular Formula	C₁₁H₁₅Cl₂N₅
Molecular Weight	288.17600
Flash Point	196.1ºC
Exact Mass	287.07000
PSA	80.00000
LogP	2.66430
Vapour Pressure	1.25E-06mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU2625000

CHEMICAL NAME :: Cycloguanil hydrochloride

CAS REGISTRY NUMBER :: 152-53-4

LAST UPDATED :: 199106

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H14-Cl-N5.Cl-H

MOLECULAR WEIGHT :: 288.21

WISWESSER LINE NOTATION :: T6N CN EN BHJ AR DG& B1 B1 DZ FZ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 54 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,487,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ATMPA2 Annals of Tropical Medicine and Parasitology. (Grune & Stratton, Inc., POB 6280, Duluth, MN 55806) V.1- 1907- Volume(issue)/page/year: 74,393,1980

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,487,1971

Hazard Codes	Xi

Precursor 3
4022-81-5 67-64-1 106-47-8
DownStream 1
5405-65-2