DC Chemicals Limited
China
Product Name: FPL64176
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: FPL 64176
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

120934-96-5

120934-96-5 structure

120934-96-5 structure

Name: FPL64176
Chemical Name: fpl 64176
CAS Number: 120934-96-5
Molecular Formula: C₂₂H₂₁NO₃
Molecular Weight: 347.40700
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2018-12-29 15:48:56
Modify Date: 2024-01-09 18:20:21
FPL64176, a nondihydropyridine compound, is a potent agonist of L-type Ca2+ channels with an EC50 value of 16 nM[1][2].

Name	fpl 64176
Synonyms	2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxlic acid methyl ester MFCD00274043 methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate

Description	FPL64176, a nondihydropyridine compound, is a potent agonist of L-type Ca2+ channels with an EC50 value of 16 nM[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
References	[1]. Zheng W, Rampe D, Triggle DJ. Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations. Mol Pharmacol. 1991 Nov;40(5):734-41. [2]. Baxter AJ, Dixon J, Ince F, Manners CN, Teague SJ. Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator. J Med Chem.

Density	1.174g/cm3
Boiling Point	547.8ºC at 760mmHg
Melting Point	144 - 145 °C
Molecular Formula	C₂₂H₂₁NO₃
Molecular Weight	347.40700
Flash Point	285.1ºC
Exact Mass	347.15200
PSA	59.16000
LogP	4.23990
Vapour Pressure	4.72E-12mmHg at 25°C
Index of Refraction	1.6
Storage condition	2-8°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

166319-19-3 structure

166319-19-3

~86%

120934-96-5 structure

120934-96-5

Literature: Santiago, Braulio; Dalton, Christopher R.; Huber, Edward W.; Kane, John M. Journal of Organic Chemistry, 1995 , vol. 60, # 15 p. 4947 - 4950

69687-80-5 structure

69687-80-5

~%

120934-96-5 structure

120934-96-5

Literature: Baxter; Dixon; Ince; Manners; Teague Journal of Medicinal Chemistry, 1993 , vol. 36, # 19 p. 2739 - 2744

32832-95-4 structure

32832-95-4

~%

120934-96-5 structure

120934-96-5

Literature: Santiago, Braulio; Dalton, Christopher R.; Huber, Edward W.; Kane, John M. Journal of Organic Chemistry, 1995 , vol. 60, # 15 p. 4947 - 4950

4755-81-1 structure

4755-81-1

~%

120934-96-5 structure

120934-96-5

Literature: Baxter; Fuher; Teague Synthesis, 1994 , # 2 p. 207 - 211

61608-94-4 structure

61608-94-4

~%

120934-96-5 structure

120934-96-5

Literature: Baxter; Fuher; Teague Synthesis, 1994 , # 2 p. 207 - 211

55810-66-7 structure

55810-66-7

~%

120934-96-5 structure

120934-96-5

Literature: Baxter; Fuher; Teague Synthesis, 1994 , # 2 p. 207 - 211

950203-40-4 structure

950203-40-4

~%

120934-96-5 structure

120934-96-5

Literature: Baxter; Fuher; Teague Synthesis, 1994 , # 2 p. 207 - 211

120935-94-6 structure

120935-94-6

~%

120934-96-5 structure

120934-96-5

Literature: Baxter; Dixon; Ince; Manners; Teague Journal of Medicinal Chemistry, 1993 , vol. 36, # 19 p. 2739 - 2744

69687-80-5 structure

69687-80-5

42908-86-1 structure

42908-86-1

71-43-2 structure

71-43-2

~%

120934-96-5 structure

120934-96-5

Literature: Dalton, Christopher R.; Kane, John M.; Rampe, David Tetrahedron Letters, 1992 , vol. 33, # 39 p. 5713 - 5716

Precursor 8
69687-80-5 32832-95-4 4755-81-1 61608-94-4
55810-66-7 120935-94-6 42908-86-1 71-43-2
DownStream 0