263717-53-9
263717-53-9 structure
- Name: PPT
- Chemical Name: 1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole
- CAS Number: 263717-53-9
- Molecular Formula: C24H22N2O3
- Molecular Weight: 386.44
- Catalog: Research Areas Cancer
- Create Date: 2018-06-21 19:59:03
- Modify Date: 2025-08-27 10:22:53
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Propyl pyrazole triol (PPT) is an estrogen receptor alpha (ERσ) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%)[1].
| Name | 1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole |
|---|---|
| Synonyms |
Phenol, 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)tris-
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole 4,4',4''-(4-Propyl-1H-pyrazole-1,3,5-triyl)triphenol 4-[2,3-bis(4-hydroxyphenyl)-4-propyl-1H-pyrazol-5-ylidene]cyclohexa-2,5-dien-1-one 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol Propyl pyrazole triol |
| Description | Propyl pyrazole triol (PPT) is an estrogen receptor alpha (ERσ) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%)[1]. |
|---|---|
| Related Catalog | |
| Target |
Estrogen receptor alpha[1] |
| In Vitro | The EC50 of Propyl pyrazole triol for the ERα-dependent response is 140 pM in ERα-U2OS-Luc cells[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 630.0±55.0 °C at 760 mmHg |
| Melting Point | 230 ºC (decomp) |
| Molecular Formula | C24H22N2O3 |
| Molecular Weight | 386.44 |
| Flash Point | 334.8±31.5 °C |
| Exact Mass | 386.163055 |
| PSA | 78.51000 |
| LogP | 5.95 |
| Appearance | solid,off-white |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.642 |
| Storage condition | 2-8°C |
| Water Solubility | Practically insoluble (0.016 g/L) (25 ºC) |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |