263717-53-9

263717-53-9 structure

Name: PPT
Chemical Name: 1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole
CAS Number: 263717-53-9
Molecular Formula: C₂₄H₂₂N₂O₃
Molecular Weight: 386.44
Catalog: Research Areas Cancer
Create Date: 2018-06-21 19:59:03
Modify Date: 2024-01-16 20:54:19
Propyl pyrazole triol (PPT) is an estrogen receptor alpha (ERσ) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%)[1].

Name	1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole
Synonyms	Phenol, 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)tris- 1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole 4,4',4''-(4-Propyl-1H-pyrazole-1,3,5-triyl)triphenol 4-[2,3-bis(4-hydroxyphenyl)-4-propyl-1H-pyrazol-5-ylidene]cyclohexa-2,5-dien-1-one 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol Propyl pyrazole triol

Description	Propyl pyrazole triol (PPT) is an estrogen receptor alpha (ERσ) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%)[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
Target	Estrogen receptor alpha[1]
In Vitro	The EC50 of Propyl pyrazole triol for the ERα-dependent response is 140 pM in ERα-U2OS-Luc cells[1].
References	[1]. https://www.ncbi.nlm.nih.gov/pubmed/18644836/ [2]. Stauffer SR, et al. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem. 2000 Dec 28;43(26):4934-47.

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