112246-15-8

112246-15-8 structure

Name: 20(R)-Ginsenoside Rh2
Chemical Name: ginsenoside Rh2
CAS Number: 112246-15-8
Molecular Formula: C₃₆H₆₂O₈
Molecular Weight: 622.873
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-08-04 12:38:46
Modify Date: 2024-01-02 21:26:07
20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity[1][2][3].

Name	ginsenoside Rh2
Synonyms	(3β,12β,20R)-12,20-Dihydroxydammar-24-en-3-yl β-D-glucopyranoside 20(R)-Ginsenoside Rh2 20(R)-Ginsenoside-Rh2 b-D-Glucopyranoside, (3b,12b,20R)-12,20-dihydroxydammar-24-en-3-yl Ginsenoside-Rh2 (R) Ginsenoside Rh2 (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl beta-d-glucopyranoside 20-(R)-Ginsenoside Rh2 β-D-Glucopyranoside, (3β,12β,20R)-12,20-dihydroxydammar-24-en-3-yl 20(R)-GINSENOSIDERH2 Ginsenoside Rh2, 20(R)-

Description	20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
References	[1]. Choi WY, et al. Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes. J Pharm Pharmacol. 2013 Feb;65(2):310-6. [2]. Chung KS, et al. Ginsenoside Rh2 induces cell cycle arrest and differentiation in human leukemia cells by upregulating TGF-β expression. Carcinogenesis. 2013 Feb;34(2):331-40. [3]. Choi S, et al. Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases. Pharm Res. 2009 Oct;26(10):2280-8.

127750-93-0

112246-15-8

Literature: Atopkina, Lyubov N.; Uvarova, Nina I.; Elyakov, Georgi B. Carbohydrate Research, 1997 , vol. 303, # 4 p. 449 - 451

Precursor 1
127750-93-0
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