298197-04-3
298197-04-3 structure
- Name: Fatostatin
- Chemical Name: fatostatin
- CAS Number: 298197-04-3
- Molecular Formula: C18H19BrN2S
- Molecular Weight: 375.326
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Fatty Acid Synthase (FAS)
- Create Date: 2016-07-06 14:25:40
- Modify Date: 2025-08-21 18:02:42
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Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice[1][2].
| Name | fatostatin |
|---|---|
| Synonyms |
2-(2-propylpyridin-4-yl)-4-p-tolylthiazole hydrobromide
FATOSTATIN A Fatostatin (hydrobromide) 4-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-2-propylpyridine hydrobromide (1:1) Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-, hydrobromide (1:1) FATOSTATIN (2-(2-PROPYLPYRIDIN-4-YL)-4-(P-TOLYL)THIAZOLE) Fatostatin A Hydrobromide |
| Description | Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Fatostatin hydrobromide (125B11 hydrobromide) (0.1-1 μM; 3 days) inhibits the androgen-independent prostate cancer cell proliferation (IC50=0.1 μM) in an independent of the known IGF1-signaling pathway. Fatostatin hydrobromide inhibits insulin-induced adipogenesis of 3T3-L1 cells[1]. Cell Proliferation Assay[1] Cell Line: DU-145 cells Concentration: 0.1, 1 μM Incubation Time: 3 days Result: Impaired the IGF1-induced growth at an IC50 of 0.1 μM. |
| In Vivo | Fatostatin hydrobromide (125B11 hydrobromide) (30 mg/kg; 150 mL; i.p.; daily for 28 days) reduces adiposity, ameliorates fatty liver by reducing triglyceride (TG) storage, and lowers hyperglycemia in ob/ob mice[2]. Animal Model: Four-to-five-week-old homozygous male obese (ob/ob) mice (C57BL/6J)[2] Dosage: 30 mg/kg; 150 mL Administration: i.p. injection; daily for 28 days Result: Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake. |
| References |
| Molecular Formula | C18H19BrN2S |
|---|---|
| Molecular Weight | 375.326 |
| Exact Mass | 374.045227 |
| PSA | 54.02000 |
| LogP | 6.09110 |
| Storage condition | -20℃ |
