Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Tedizolid Phosphate
Price: ￥606.0/50mg ￥2026.0/250mg ￥1016.0/100mg ￥406.0/25mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Torezolid phosphate
Price: $400.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: tedizolid phosphate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

856867-55-5

856867-55-5 structure

856867-55-5 structure

Name: Tedizolid Phosphate
Chemical Name: tedizolid phosphate
CAS Number: 856867-55-5
Molecular Formula: C₁₇H₁₆FN₆O₆P
Molecular Weight: 450.318
Catalog: API Synthetic anti-infective drugs Antifungal drugs
Create Date: 2018-08-08 10:31:56
Modify Date: 2024-01-02 17:56:16
Tedizolid phosphate is a novel oxazolidinone with activity against Gram-positive pathogens.

Name	tedizolid phosphate
Synonyms	2-Oxazolidinone, 3-[3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-[(phosphonooxy)methyl]- TR-701 FA Torezolid phosphate UNII-O7DRJ6R4DW Tedizolid phosphate [(5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)pyridin-3-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl dihydrogen phosphate (3-{3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl dihydrogen phosphate Tedizolid (phosphate)

Description	Tedizolid phosphate is a novel oxazolidinone with activity against Gram-positive pathogens.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
In Vitro	Tedizolid (0.25 μg/mL) inhibits all 28 clinical isolates of PRSP, and is 4-fold more potent than linezolid against PRSP[1].
In Vivo	For mice infected with PSSP type III, the 100% survival rate is achieved with tedizolid phosphate at a minimum total daily dose of 10 mg/kg. Lungs of infected mice treated with tedizolid phosphate show less severe inflammation and edema, as indicated by the mean scores for inflammation and edema[1].
Animal Admin	To induce a systemic S. pneumoniae infection, male ICR mice (weight, 18 to 20 g) are inoculated intraperitoneally with 1 of 4 PRSP isolates (DR9, DR10, DR11, or DR14) suspended in 10% mucin. The suspension contained sufficient bacteria to kill 100% of untreated control mice. At 1 h postinfection, mice receives a single dose of either tedizolid phosphate or linezolid, and survival is assessed daily for 7 days postinfection. Treatments are delivered both orally and intravenously at each of four doses (40 mg/kg of body weight, 13.33 mg/kg, 4.44 mg/kg, and 1.48 mg/kg), with 8 mice per group defined by dose, delivery method, and infecting strain. The 50% effective dose (ED50), i.e., the dose allowing survival of 50% of the infected mice, is calculated for each delivery route using probit analysis.
References	[1]. Choi S, et al. Activity of Tedizolid Phosphate (TR-701) in Murine Models of Infection with Penicillin-resistant and Penicillin-sensitive Streptococcus pneumoniae. Antimicrob Agents Chemother. 2012 Jun 19.

Density	1.8±0.1 g/cm3
Boiling Point	725.6±70.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₆FN₆O₆P
Molecular Weight	450.318
Flash Point	392.6±35.7 °C
Exact Mass	450.085297
PSA	162.60000
LogP	0.69
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.739
Storage condition	2-8°C