443798-55-8

443798-55-8 structure

Name: Cdk1/2 Inhibitor III
Chemical Name: 5-amino-N-(2,6-difluorophenyl)-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide
CAS Number: 443798-55-8
Molecular Formula: C₁₅H₁₃F₂N₇O₂S₂
Molecular Weight: 425.43600
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2017-06-29 02:24:35
Modify Date: 2024-01-15 19:57:20
Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor, with an IC50 of 2.1 μM for CDK1/cyclin B[1].

Name	5-amino-N-(2,6-difluorophenyl)-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide
Synonyms	CDK 1/2 INHIBITOR Cdk1/2 Inhibitor III HMS3229C16 2wu6

Description	Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor, with an IC50 of 2.1 μM for CDK1/cyclin B[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	Cdk1/cyclin B:2.1 μM (IC50)
In Vitro	Cdk1/2 Inhibitor III has weak CDK1 and cellular antiproliferative potencies[1].
References	[1]. Lin R, et al. Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities. J Med Chem. 2005 Jun 30;48(13):4208-11.