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2622-08-4

2622-08-4 structure
2622-08-4 structure

Name tris(2-methylphenyl) phosphite
Synonyms Tri-o-cresyl Phosphite
Tri-o-tolyl phosphite
Phosphorous Acid Tri-o-cresyl Ester
MFCD00014911
Tris(2-methylphenyl) Phosphite
TRI-2-TOLYLPHOSPHITE
EINECS 220-068-7
Phosphorous Acid Tri-o-tolyl Ester
Phosphorous Acid Tris(2-methylphenyl) Ester
Boiling Point 200-202°C/2.4-2.6mm
Molecular Formula C21H21O3P
Molecular Weight 352.36300
Flash Point 200-202°C/2.4-2.6mm
Exact Mass 352.12300
PSA 41.28000
LogP 6.37550
Vapour Pressure 6.01E-14mmHg at 25°C
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TH1050000
CHEMICAL NAME :
Phosphorous acid, tri-o-cresyl ester
CAS REGISTRY NUMBER :
2622-08-4
LAST UPDATED :
199409
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C21-H21-O6-P
MOLECULAR WEIGHT :
400.39
WISWESSER LINE NOTATION :
QR B1OPO1R BQ&O1R BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - tremor Behavioral - muscle weakness
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 49,78,1933
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - tremor Behavioral - muscle weakness
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 49,78,1933 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
900 mg/kg/90D-I
TOXIC EFFECTS :
Spinal Cord - other degenerative changes Behavioral - ataxia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 53,150,1980
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36
RTECS TH1050000
HS Code 2920901900

~92%

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Literature: Pandey, Rajesh K.; Wakharkar; Kumar, Pradeep Synthetic Communications, 2005 , vol. 35, # 21 p. 2795 - 2800

~14%

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Literature: Ritter, Joachim C. Patent: US2004/106815 A1, 2004 ; Location in patent: Page 12-13 ;

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Literature: Ivanov, B. E.; Badeeva, E. K.; Krokhina, S. S. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1988 , vol. 37, # 11 p. 2371 - 2373 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1988 , # 11 p. 2632 - 2634

~38%

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Literature: Budnikova, Yu. G.; Kargin, Yu. M.; Zaripov, I. M.; Romakhin, A. S.; Ignat'ev, Yu. A.; et al. Bull. Russ. Acad. Sci. Div. Chem. Sci. (Engl. Transl.), 1992 , vol. 41, # 9.1 p. 2039 - 2043,1585 - 1588

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2622-08-4

Detail
Literature: Tolman, Chadwick A. Organometallics, 1983 , vol. 2, p. 614 - 621

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Literature: Strecker; Grossmann Chemische Berichte, 1916 , vol. 49, p. 75 Full Text Show Details Raschig Patent: DE233631 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 10, p. 164
HS Code 2920901900
Summary 2920901900 VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%