400827-46-5
400827-46-5 structure
- Name: Ceftaroline fosamil
- Chemical Name: ceftaroline fosamil acetate
- CAS Number: 400827-46-5
- Molecular Formula: C24H25N8O10PS4
- Molecular Weight: 744.74
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2018-05-26 08:00:00
- Modify Date: 2024-01-03 18:20:07
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Ceftaroline fosamil is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).
| Name | ceftaroline fosamil acetate |
|---|---|
| Synonyms |
Teflaro
(6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,acetate Ceftaroline fosamil PPI 0903 (6R,7R)-7-({(2E)-2-(Ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl}amino)-3-{[4-(1-methyl-4-pyridiniumyl)-1,3-thiazol-2-yl]sulfanyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Ceftaroline fosamil acetate anhydrous Pyridinium, 4-[2-[[(6R,7R)-2-carboxy-7-[[(2E)-2-(ethoxyimino)-1-oxo-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]ethyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methyl-, inner salt UNII-EZ9W6O5S09 Zinforo Ceftaroline fosamil acetate TAK-599 |
| Description | Ceftaroline fosamil is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). |
|---|---|
| Related Catalog | |
| In Vivo | Ceftaroline fosamil is effective against all 10 MRSA isolates used in the dose-ranging studies and requires approximately 17 to 43% fT>MIC (the percentage of time that free drug concentrations remain above the MIC) to produce a 1-log10 kill[1]. The Ceftaroline Fosamil treatment results in mean reductions of 1.1 to 2.4 log10 CFU, with no relationship to the Ceftaroline Fosamil MIC. The use of high inocula does not affect the Ceftaroline Fosamil efficacy against the three strains tested, with mean decreases of 2.0 to 3.0 log10 CFU[2]. |
| Animal Admin | Seventeen clinical S. aureus isolates (2 MSSA, 15 MRSA) are studied using the neutropenic lung infection model. Beginning 3 h after inoculation, groups of six mice receive treatment with Ceftaroline fosamil over a 24 h period. Ceftaroline fosamil doses are administered as 0.2 mL subcutaneous injections. Control animals are administered normal saline at the same volume, route, and frequency as the treatment regimens[1]. |
| References |
| Molecular Formula | C24H25N8O10PS4 |
|---|---|
| Molecular Weight | 744.74 |
| PSA | 346.85000 |
| LogP | -2.84 |
| Storage condition | 2-8℃ |