760173-05-5
760173-05-5 structure
- Name: Etamicastat
- Chemical Name: 4-(2-aminoethyl)-3-[(3R)-6,8-difluoro-3,4-dihydro-2H-chromen-3-yl]-1H-imidazole-2-thione
- CAS Number: 760173-05-5
- Molecular Formula: C14H15F2N3OS
- Molecular Weight: 311.35
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-08-01 17:27:55
- Modify Date: 2025-08-25 16:57:07
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Etamicastat (BIA 5-453) is a potent and reversible peripheral dopamine-β-hydroxylase (DβH) inhibitor[1].
| Name | 4-(2-aminoethyl)-3-[(3R)-6,8-difluoro-3,4-dihydro-2H-chromen-3-yl]-1H-imidazole-2-thione |
|---|---|
| Synonyms |
UNII-9X96V6DBU4
Etamitat |
| Description | Etamicastat (BIA 5-453) is a potent and reversible peripheral dopamine-β-hydroxylase (DβH) inhibitor[1]. |
|---|---|
| Related Catalog | |
| Target |
Dopamine-β-hydroxylase (DβH)[1] |
| In Vivo | Upon intraperitoneal administration to NMRi mice, Etamicastat (100 mg/ kg) leads to a significant reduction of noradrenaline levels (36% control) in heart with concomitant increasing in dopamine levels (850% of control)[2]. Etamicastat (50 mg/kg) is rapidly absorbed into the systemic circulation reaching a maximum concentration at 4 h post-administration, representing 29% of total Etamicastat and quantified metabolites, using AUC0-t as a measure of systemic exposure[2]. |
| References |
| Density | 1.44 |
|---|---|
| Boiling Point | 435.308ºC at 760 mmHg |
| Molecular Formula | C14H15F2N3OS |
| Molecular Weight | 311.35 |
| Flash Point | 217.067ºC |
| Exact Mass | 311.09000 |
| PSA | 91.87000 |
| LogP | 2.82770 |
| Precursor 8 | |
|---|---|
| DownStream 0 | |
![(R)-2-{2-[3--(6,8-difluorochroman-3-yl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl]ethyl}isoindole-1,3-dione structure](https://image.chemsrc.com/caspic/464/1044596-95-3.png)
