83467-48-5

83467-48-5 structure

Name: 3’-O-(t-Butyldiphenylsilyl) thymidine
Chemical Name: 2'-Deoxy-3'-O-[(2-methyl-2-propanyl)(diphenyl)silyl]-3,4-dihydrot hymidine
CAS Number: 83467-48-5
Molecular Formula: C₁₀H₁₃DTBN₂O₅PS
Molecular Weight: 320.10
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2016-10-30 19:56:38
Modify Date: 2024-01-13 11:02:45
3’-O-(t-Butyldiphenylsilyl) thymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	2'-Deoxy-3'-O-[(2-methyl-2-propanyl)(diphenyl)silyl]-3,4-dihydrot hymidine
Synonyms	2'-deoxy-3'-tert-butyldiphenylsilyl-thymidine 3'-O-(t-butyldiphenylsilyl)thymidine 3'-O-(tert-butyldimethylsilyl)adenosine 3'-O-tert-butyldiphenylsilyl-2'-deoxythymidine O3'-(tert-butyl-dimethyl-silanyl)-adenosine 3'-O-(tert-butyldiphenylsilyl)thymidine 1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 3'-O-TBDPS-thymidine

Description	3’-O-(t-Butyldiphenylsilyl) thymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.