1019331-10-2
1019331-10-2 structure
- Name: S0859
- Chemical Name: 2-chloro-N-[[4-[2-(cyanosulfamoyl)phenyl]phenyl]methyl]-N-[(4-methylphenyl)methyl]benzamide
- CAS Number: 1019331-10-2
- Molecular Formula: C29H24ClN3O3S
- Molecular Weight: 530.037
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Na+/HCO3- Cotransporter
- Create Date: 2017-07-08 01:14:18
- Modify Date: 2024-01-02 14:57:15
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S0859, an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). IC50 value:Target: NBCNa(+)-coupled HCO(3)(-) transporters (NBCs) mediate the transport of bicarbonate ions across cell membranes and are thus ubiquitous regulators of intracellular pH. NBC dysregulation is associated with a range of diseases; for instance, NBCn1 is strongly up-regulated in a model of ErbB2-dependent breast cancer, a malignant and widespread cancer with no targeted treatment options, and single-nucleotide polymorphisms in NBCn1 genetically link to breast cancer development and hypertension. Treatment with NBC inhibitor S0859 significantly increased caspase-3 activity and elevated the number of apoptotic EC. S0859 is potentially important for probing the transporter's functional role in heart and other tissues.
| Name | 2-chloro-N-[[4-[2-(cyanosulfamoyl)phenyl]phenyl]methyl]-N-[(4-methylphenyl)methyl]benzamide |
|---|---|
| Synonyms |
CS-1092
Benzamide, 2-chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]- QCR-54 S-0859 2-Chloro-N-{[2'-(cyanosulfamoyl)-4-biphenylyl]methyl}-N-(4-methylbenzyl)benzamide 2-chloro-N-((2'-(N-cyanosulfamoyl)biphenyl-4-yl)methyl)-N-(4-methylbenzyl)benzamide S0859 |
| Description | S0859, an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). IC50 value:Target: NBCNa(+)-coupled HCO(3)(-) transporters (NBCs) mediate the transport of bicarbonate ions across cell membranes and are thus ubiquitous regulators of intracellular pH. NBC dysregulation is associated with a range of diseases; for instance, NBCn1 is strongly up-regulated in a model of ErbB2-dependent breast cancer, a malignant and widespread cancer with no targeted treatment options, and single-nucleotide polymorphisms in NBCn1 genetically link to breast cancer development and hypertension. Treatment with NBC inhibitor S0859 significantly increased caspase-3 activity and elevated the number of apoptotic EC. S0859 is potentially important for probing the transporter's functional role in heart and other tissues. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 748.5±70.0 °C at 760 mmHg |
| Molecular Formula | C29H24ClN3O3S |
| Molecular Weight | 530.037 |
| Flash Point | 406.5±35.7 °C |
| Exact Mass | 529.122681 |
| PSA | 98.65000 |
| LogP | 5.68 |
| Appearance | white solid |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.639 |
| Storage condition | -20℃ |
| Hazard Statements | H413 |
|---|---|
| RIDADR | NONH for all modes of transport |