Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Sphondin
Price: ￥2880.0/5mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Sphondin
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: SPHONDIN
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

483-66-9

483-66-9 structure

Name: Sphondin
Chemical Name: 6-methoxyfuro[2,3-h]chromen-2-one
CAS Number: 483-66-9
Molecular Formula: C₁₂H₈O₄
Molecular Weight: 216.189
Catalog: Natural product Coumarin
Create Date: 2018-08-02 08:47:59
Modify Date: 2025-08-22 13:34:30
Sphondin, isolated from Heracleum laciniatum, possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells[1].

Name	6-methoxyfuro[2,3-h]chromen-2-one
Synonyms	6-Methoxy-2H-furo[2,3-h]chromen-2-one Sfondin 6-Methoxyfuro[2,3-h]chromen-2-one 2H-Furo[2,3-h]-1-benzopyran-2-one, 6-methoxy- 6-Methoxy-2H-furo(2,3-h)-1-benzopyran-2-one Sphondin 6-Methoxy-furano-<2',3'-7,8>cumarin,Sphondin

Description	Sphondin, isolated from Heracleum laciniatum, possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2
In Vitro	Pretreatment of A549 cells with Sphondin (10-50 μM) concentration-dependently attenuates IL-1β-induced COX-2 protein expression and PGE2 release[1].
References	[1]. Ling Ling Yang, et al. Effects of Sphondin, Isolated From Heracleum Laciniatum, on IL-1beta-induced cyclooxygenase-2 Expression in Human Pulmonary Epithelial Cells. Life Sci. 2002 Nov 29;72(2):199-213.

Density	1.4±0.1 g/cm3
Boiling Point	413.0±45.0 °C at 760 mmHg
Molecular Formula	C₁₂H₈O₄
Molecular Weight	216.189
Flash Point	203.6±28.7 °C
Exact Mass	216.042252
PSA	52.58000
LogP	1.83
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.635

Hazard Codes	Xi

116669-19-3

~82%

483-66-9

Literature: Wulff, William D.; McCallum, J. Stuart; Kunng, Fen-Ann Journal of the American Chemical Society, 1988 , vol. 110, # 22 p. 7419 - 7434

116663-87-7

~50%

483-66-9

Literature: Wulff, William D.; McCallum, J. Stuart; Kunng, Fen-Ann Journal of the American Chemical Society, 1988 , vol. 110, # 22 p. 7419 - 7434

61265-07-4

77-78-1

~37%

483-66-9

131-12-4

Literature: Sardari, Soroush; Mori, Yoki; Horita, Kiyoshi; Micetich, Ronald G.; Nishibe, Sansei; Daneshtalab, Mohsen Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1933 - 1940

116663-85-5

483-66-9

Literature: Wulff, William D.; McCallum, J. Stuart; Kunng, Fen-Ann Journal of the American Chemical Society, 1988 , vol. 110, # 22 p. 7419 - 7434

116663-86-6

483-66-9

Literature: Wulff, William D.; McCallum, J. Stuart; Kunng, Fen-Ann Journal of the American Chemical Society, 1988 , vol. 110, # 22 p. 7419 - 7434

250639-95-3

483-66-9

Literature: Sardari, Soroush; Mori, Yoki; Horita, Kiyoshi; Micetich, Ronald G.; Nishibe, Sansei; Daneshtalab, Mohsen Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1933 - 1940

462094-30-0

~3%

483-66-9

Literature: Chimichi, Stefano; Boccalini, Marco; Cosimelli, Barbara; Viola, Giampietro; Vedaldi, Daniela; Dall'Acqua, Francesco Tetrahedron, 2002 , vol. 58, # 24 p. 4859 - 4863

Precursor 3
61265-07-4 77-78-1 250639-95-3
DownStream 1
574-84-5

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483-66-9	949438-30-6
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84671-59-0	929433-45-4
1027518-88-2	847403-31-0
101980-47-6