14756-24-2
14756-24-2 structure
- Name: DiMNF
- Chemical Name: 2-(3,4-dimethoxyphenyl)benzo[h]chromen-4-one
- CAS Number: 14756-24-2
- Molecular Formula: C21H16O4
- Molecular Weight: 332.34900
- Catalog: Signaling Pathways Immunology/Inflammation Aryl Hydrocarbon Receptor
- Create Date: 2018-12-26 22:26:08
- Modify Date: 2025-10-03 19:21:19
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DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent[1].
| Name | 2-(3,4-dimethoxyphenyl)benzo[h]chromen-4-one |
|---|---|
| Synonyms |
2-(3,4-Dimethoxyphenyl)-benzo[h]chromen-4-one
2-(3,4-dimethoxy-phenyl)-benzo[h]chromen-4-one 2-(3,4-Dimethoxy-phenyl)-benzo[h]chromen-4-on 2-(3,4-dimethoxyphenyl)-4h-benzo[h]chromen-4-one DiMNF |
| Description | DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent[1]. |
|---|---|
| Related Catalog | |
| In Vitro | DiMNF (3',4'-Dimethoxy-αNF) (10 μM; 4 h) minimally influences AHR gene battery[1]. DiMNF (10 μM; 1 h) effectively suppresses cytokine-mediated inflammatory gene expression[1]. DiMNF adopts a unique orientation within the ligand binding pocket of AHR[1]. RT-PCR[1] Cell Line: Huh7 cell Concentration: 10 μM Incubation Time: 4 h or 1 h Result: Decreased CYP1A1 mRNA expression (4 h). Exhibited repressive activity toward cytokine-mediated SAA1 induction (1 h). Significantly reduced IL1β-mediated mRNA induction of C4, C1S, C1R, and C3. |
| References |
| Density | 1.271g/cm3 |
|---|---|
| Boiling Point | 513.8ºC at 760 mmHg |
| Molecular Formula | C21H16O4 |
| Molecular Weight | 332.34900 |
| Flash Point | 227.3ºC |
| Exact Mass | 332.10500 |
| PSA | 48.67000 |
| LogP | 4.63040 |
| Vapour Pressure | 1.15E-10mmHg at 25°C |
| Index of Refraction | 1.65 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
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~65%
14756-24-2 |
| Literature: Juvale, Kapil; Stefan, Katja; Wiese, Michael European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 115 - 126 |
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14756-24-2 |
| Literature: European Journal of Medicinal Chemistry, , vol. 67, p. 115 - 126 |
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14756-24-2 |
| Literature: European Journal of Medicinal Chemistry, , vol. 67, p. 115 - 126 |
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14756-24-2 |
| Literature: Jahrbuch der Philosophischen Fakultaet 2 [Zweite] der Universitaet Bern, , vol. 4, p. 93 |
