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36804-95-2

36804-95-2 structure
36804-95-2 structure

Name deoxyharringtonine
Synonyms (-)-deoxyharringtonine
Description Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity[1].
Related Catalog
In Vitro Deoxyharringtonine 作用于 P388 白血病细胞的 IC50 值为 7.5 ng/mL。此外,其对造血细胞系如 HL-60、HL-60/RV+、JURKAT、ALL3、NCEB1、JEKO、MOLT-3 等具有极强的细胞毒活性[1]。
References

[1]. Joseph D Eckelbarger, et al. Synthesis of antiproliferative Cephalotaxus esters and their evaluation against several human hematopoietic and solid tumor cell lines: uncovering differential susceptibilities to multidrug resistance. Chemistry. 2008;14(14):4293-306.   

Density 1.3g/cm3
Boiling Point 645.8ºC at 760mmHg
Molecular Formula C28H37NO8
Molecular Weight 515.59500
Flash Point 344.4ºC
Exact Mass 515.25200
PSA 103.76000
LogP 3.01360
Index of Refraction 1.595

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FK0279000
CHEMICAL NAME :
Cephalotaxine, 4-methyl-, 2-hydroxy-2-(3-methylbutyl)butanedioate (ester), (3(R))-
CAS REGISTRY NUMBER :
36804-95-2
LAST UPDATED :
199209
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C28-H37-N-O8
MOLECULAR WEIGHT :
515.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988