190448-57-8

190448-57-8 structure

Name: Ezetimibe phenoxy glucuronide
Chemical Name: (2S,3S,4S,5R,6S)-6-[4-[(2S,3R)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2-yl]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
CAS Number: 190448-57-8
Molecular Formula: C₃₀H₂₉F₂NO₉
Molecular Weight: 585.54900
Catalog: Research Areas Metabolic Disease
Create Date: 2016-03-20 04:23:03
Modify Date: 2024-01-02 12:14:48
Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].

Name	(2S,3S,4S,5R,6S)-6-[4-[(2S,3R)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2-yl]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
Synonyms	Ezetimibe Phenoxy Glucuronide ezetimibe-glucuronide EZM-G

Description	Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	After oral administration, Ezetimibe is absorbed in the small intestine and more than 80% of Ezetimibe metabolized to Ezetimibe Glucuronide[1].
References	[1]. Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11. [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.