Name | moxalactam |
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Synonyms |
5-Oxa-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid,7-((carboxy(4-hydroxyphenyl)acetyl) amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo
7-((Carboxy(4-hydroxyphenyl)acetyl)amino)-7-methoxy-(3-((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Latamoxef lamoxactam (R)-Moxalactam 5-oxa-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-((carboxy(4-hydroxyphen Listeria MOX Supplement,Moxalactam Oxa-cephem yl)acetyl)amino)-7-methoxy-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo LMOX |
Description | Moxalactam (Latamoxef) is a synthetic oxa-β-lactam antibiotic. Moxalactam has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Moxalactam inhibits production of β-lactamases[1]. |
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Related Catalog | |
Target |
β-lactamases[1] |
In Vitro | Moxalactam (Latamoxef) inhibits 90% of strains of Escherichia coli, Klebsiella species, Proteus species, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae and Salmonella species, including strains which are resistant to Cephalothin (HY-B1275A) and Gentamicin (HY-A0276A) at concentrations of less than 1 μg/mL[1]. Moxalactam exhibits moderate activity against P. aeruginosa and is usually active against other species of Pseudomonas, Acinetobacter species are usually resistant to Moxalactam[1]. Moxalactam has marked stability in vitro against a variety of β-lactamases, including that produced by B. fragilis, inhibits production of β-lactamases and does not induce class I β-lactamase[1]. |
In Vivo | Moxalactam (Latamoxef) (0-7.4 mg/mouse; s.c.; once) is effective against bacterial infections in mice[2]. Animal Model: Four-week-old male strain ICR mice, weighing 18-20 g, bacterial infection model[2] Dosage: 0-7.4 mg/mouse Administration: Subcutaneous injection, once Result: Showed protective activity with ED50s less than 7.4 mg/mouse against gram-positive and gram-negative bacterial infected mice. |
References |
Density | 1.77 g/cm3 |
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Boiling Point | 836ºC |
Melting Point | 117 - 122ºC |
Molecular Formula | C20H20N6O9S |
Molecular Weight | 520.47300 |
Exact Mass | 520.10100 |
PSA | 231.60000 |
Index of Refraction | 1.768 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | RN6824500 |