6068-78-6

6068-78-6 structure

Name: 3',4'-Dihydroxyflavonol
Chemical Name: 2-(3,4-dihydroxyphenyl)-3-hydroxychromen-4-one
CAS Number: 6068-78-6
Molecular Formula: C₁₅H₁₀O₅
Molecular Weight: 270.24
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2018-08-13 20:12:28
Modify Date: 2025-08-25 19:53:40
3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant, which reduces superoxide and improves nitric oxide (NO) function in diabetic rat mesenteric arteries[1].

Name	2-(3,4-dihydroxyphenyl)-3-hydroxychromen-4-one
Synonyms	3',4'-dihydroxyflavonol 3',4'-Dihydroxyflavonol 3,3',4'-TRIHYDROXYFLAVONE 3,3',4'-trihydroxyflavon 2-(3,4-dihydroxy-phenyl)-3-hydroxy-chromen-4-one

Description	3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant, which reduces superoxide and improves nitric oxide (NO) function in diabetic rat mesenteric arteries[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Metabolic Disease
In Vitro	3',4'-Dihydroxyflavonol (DiOHF) acutely preserves nitric oxide (NO) activity in the presence of elevated reactive oxygen species (ROS). DiOHF improves NO activity in diabetes by reducing Nox2-dependent superoxide production and preventing eNOS uncoupling to improve endothelial function[1]. 3',4'-Dihydroxyflavonol reduces vascular contraction through Ca²⁺ desensitization in permeabilized third-order branches of rat mesenteric arteries[2].
References	[1]. Leo CH, et al. 3',4'-Dihydroxyflavonol reduces superoxide and improves nitric oxide function in diabetic rat mesenteric arteries. PLoS One. 2011;6(6):e20813. [2]. Kim HY, et al. 3',4'-Dihydroxyflavonol reduces vascular contraction through Ca²⁺ desensitization in permeabilized rat mesenteric artery. Naunyn Schmiedebergs Arch Pharmacol. 2012 Feb;385(2):191-202.

307521-00-2

~69%

6068-78-6

Literature: Van Acker; Hageman; Haenen; Van der Vijgh; Bast; Menge Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3752 - 3760

118-93-4

6068-78-6

Literature: Van Acker; Hageman; Haenen; Van der Vijgh; Bast; Menge Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3752 - 3760

5447-02-9

6068-78-6

Literature: Van Acker; Hageman; Haenen; Van der Vijgh; Bast; Menge Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3752 - 3760

808741-39-1

6068-78-6

Literature: Van Acker; Hageman; Haenen; Van der Vijgh; Bast; Menge Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3752 - 3760

6889-80-1

~45%

6068-78-6

Literature: Sobottka; Werner; Blaschke; Kiefer; Nowe; Dannhardt; Schapoval; Schenkel; Scriba Archiv der Pharmazie, 2000 , vol. 333, # 7 p. 205 - 210

19152-36-4

6068-78-6

Literature: Sobottka; Werner; Blaschke; Kiefer; Nowe; Dannhardt; Schapoval; Schenkel; Scriba Archiv der Pharmazie, 2000 , vol. 333, # 7 p. 205 - 210

120-14-9

6068-78-6

Literature: Sobottka; Werner; Blaschke; Kiefer; Nowe; Dannhardt; Schapoval; Schenkel; Scriba Archiv der Pharmazie, 2000 , vol. 333, # 7 p. 205 - 210

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%