4004-05-1
4004-05-1 structure
- Name: DOPE
- Chemical Name: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
- CAS Number: 4004-05-1
- Molecular Formula: C41H78NO8P
- Molecular Weight: 744.034
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2018-08-16 20:42:45
- Modify Date: 2024-01-07 18:54:18
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1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA[1].
| Name | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine |
|---|---|
| Synonyms |
DOPE
9-Octadecenoic acid, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester, (9Z,9'Z)- Dioleoyl phosphoethanolamine L-A-phosphatidylethanolamine dioleoyl 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine 1,2-dioleoyl-sn-glycerol-3-phosphoethanolamine 3-SN-PHOSPHATIDYLETHANOLAMINE,1,2-DIDEOYL MFCD00057986 1,2-di-O-oleoyl-sn-glycero-3-phosphatidylethanolamine 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) 2-Ammonioethyl (2R)-2,3-bis[(9Z)-9-octadecenoyloxy]propyl phosphate 1,2-dioleoyl-sn-glycero-3-phosphoethanoloamine COATSOME ME-8181 (DOPE) DIOLEOYL PHOSPHATIDYL ETHANOLAMINE 18:1 PE |
| Description | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: helper lipid for liposome[1] |
| In Vitro | In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent)[1]. With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity[1]. LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells[1]. LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs[1]. |
| References |
| Density | 1.008g/cm3 |
|---|---|
| Boiling Point | 759.2±70.0 °C at 760 mmHg |
| Melting Point | 200 °C |
| Molecular Formula | C41H78NO8P |
| Molecular Weight | 744.034 |
| Flash Point | 413.0±35.7 °C |
| Exact Mass | 743.546509 |
| PSA | 144.19000 |
| LogP | 14.79 |
| Vapour Pressure | 0.0±5.5 mmHg at 25°C |
| Index of Refraction | 1.484 |
| Symbol |
GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H315-H319-H331-H336-H351-H361d-H372 |
| Precautionary Statements | P261-P281-P305 + P351 + P338-P311 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22;R38;R40;R48/20/22 |
| Safety Phrases | 36/37 |
| RIDADR | UN 1888 |
| Hazard Class | 6.1 |
| HS Code | 2931900090 |
|
~90%
4004-05-1 |
| Literature: Harris; Marshall; Lee; Siegel; Mcneilly; Yew; Nietupski; Nichols; Cherry; Wan; Jiang; Lane; Rowe; Scheule; Smith; Cheng Phosphorus, Sulfur and Silicon and Related Elements, 1996 , vol. 109, # 1-4 p. 289 - 292 |
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| Literature: Helvetica Chimica Acta, , vol. 74, # 8 p. 1697 - 1706 |
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| Literature: Helvetica Chimica Acta, , vol. 74, # 8 p. 1697 - 1706 |
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| Literature: Phosphorus, Sulfur and Silicon and Related Elements, , vol. 109, # 1-4 p. 289 - 292 |
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| Literature: Phosphorus, Sulfur and Silicon and Related Elements, , vol. 109, # 1-4 p. 289 - 292 |
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4004-05-1 |
| Literature: Journal of the Chemical Society. Perkin transactions 1, , vol. 12, p. 1404 - 1412 |
| Precursor 6 | |
|---|---|
| DownStream 1 | |
| HS Code | 2931900090 |
|---|---|
| Summary | 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0% |